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http://hdl.handle.net/1942/26506
Title: | Characteristics and Spontaneous Recovery of Tinnitus Related to Idiopathic Sudden Sensorineural Hearing Loss | Authors: | Muehlmeier, Guido Baguley, David COX, Tony Suckfuell, Markus Meyer, Thomas |
Issue Date: | 2016 | Source: | OTOLOGY & NEUROTOLOGY, 37(6), p. 634-641 | Abstract: | Objective: To evaluate the characteristics and spontaneous recovery of tinnitus related to idiopathic sudden sensorineural hearing loss (ISSNHL). Study Design: Retrospective analysis from two randomized placebo-controlled clinical trials for treatment of ISSNHL within 48 hours from onset (Study A), or of tinnitus related to ISSNHL within 3 months from onset (Study B). Setting: Forty-eight European sites (academic tertiary referral centers, private ENT practices). Patients: One hundred thirteen adult patients of which 65 with hearing loss >= 30 dB (Study A) and 48 with persistent acute tinnitus (Study B) at baseline. Interventions: Intratympanic (i.t.) injection of placebo gel in single dose or in triple dose during 3 consecutive days. Main Outcome Measures: Frequency of tinnitus, subjective tinnitus loudness, rates of complete tinnitus remission, and complete hearing recovery during 3 months follow-up. Results: In acute ISSNHL, tinnitus loudness decreased rapidly in cases of mild-moderate hearing loss, and tinnitus had completely resolved in two-thirds of patients after 3 months. Hearing recovery preceded tinnitus resolution. When associated with severe-profound hearing loss, tinnitus improved significantly less. Complete hearing recovery and full tinnitus remission were both about three times more frequent in mild-moderate hearing loss patients than in severe-profound cases. Improvement in tinnitus loudness over time can be approximated by a negative exponential function. Conclusions: Prognosis for ISSNHL-related tinnitus is relatively poor in case of severe-profound hearing loss and the longer it has persisted. Alleviation or management of tinnitus should be a key therapeutic objective especially in pronounced ISSNHL cases. | Keywords: | hearing recovery; intratympanic; ISSNHL; spontaneous recovery; tinnitus | Document URI: | http://hdl.handle.net/1942/26506 | ISSN: | 1531-7129 | e-ISSN: | 1537-4505 | DOI: | 10.1097/MAO.0000000000001081 | ISI #: | 000378064500008 | Rights: | Copyright © 2016 Otology & Neurotology, Inc. Unauthorized reproduction of this article is prohibited. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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