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http://hdl.handle.net/1942/26523
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DC Field | Value | Language |
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dc.contributor.author | Costa, Francesco | - |
dc.contributor.author | Adamo, Marianna | - |
dc.contributor.author | Ariotti, Sara | - |
dc.contributor.author | Ferrante, Giuseppe | - |
dc.contributor.author | Navarese, Eliano Pio | - |
dc.contributor.author | Leonardi, Sergio | - |
dc.contributor.author | Garcia-Garcia, Hector | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.date.accessioned | 2018-07-31T12:35:09Z | - |
dc.date.available | 2018-07-31T12:35:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | EUROINTERVENTION, 11(11), p. E1222-E1230 | - |
dc.identifier.issn | 1774-024X | - |
dc.identifier.uri | http://hdl.handle.net/1942/26523 | - |
dc.description.abstract | AIMS: It is currently unclear if the location of coronary artery disease affects decision making with regard to dual antiplatelet therapy (DAPT). We investigated if the presence of at least 30% luminal narrowing in the left main (LM) and/or proximal left anterior descending (pLAD) coronary arteries on angiography is an outcome modifier with respect to DAPT duration. METHODS AND RESULTS: In the Prolonging Dual Antiplatelet Treatment After Grading Stent-Induced Intimal Hyperplasia (PRODIGY) study, 953 (54.3%) patients with and 801 (45.7%) without LM/pLAD lumen narrowing at the qualifying coronary intervention were randomised to six or 24 months of DAPT. Twenty-four month as compared to six-month DAPT reduced the occurrence of definite, probable or possible stent thrombosis by 50% in patients with (2.8% vs. 5.6%; HR 0.45, 95% CI: 0.23-0.89; p=0.02) but not in those without LM/pLAD lumen narrowing, with a highly significant interaction testing (P-INT= 0.002). This result remained consistent irrespective of whether stenting was (P-INT: 0.01) or was not (P-INT: 0.02) performed in the LM/pLAD. CONCLUSIONS: Left main and/or proximal LAD lumen narrowing may be a treatment modifier with respect to the duration of DAPT. Patients fulfilling these angiographic characteristics seem to benefit from a prolonged dual antiplatelet treatment. | - |
dc.language.iso | en | - |
dc.subject.other | acute coronary syndrome; clopidogrel; dual antiplatelet therapy (DAPT); left main coronary artery; proximal left anterior descending coronary artery; stent thrombosis | - |
dc.title | Left main or proximal left anterior descending coronary artery disease location identifies high-risk patients deriving potentially greater benefit from prolonged dual antiplatelet therapy duration | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | E1230 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | E1222 | - |
dc.identifier.volume | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | dsPublValOverrule/internal_author_not_expected | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.doi | 10.4244/EIJY15M08_04 | - |
dc.identifier.isi | 000400774200006 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Costa, Francesco; Adamo, Marianna; Ariotti, Sara; Ferrante, Giuseppe; Navarese, Eliano Pio; Leonardi, Sergio; Garcia-Garcia, Hector; VRANCKX, Pascal & Valgimigli, Marco (2016) Left main or proximal left anterior descending coronary artery disease location identifies high-risk patients deriving potentially greater benefit from prolonged dual antiplatelet therapy duration. In: EUROINTERVENTION, 11(11), p. E1222-E1230. | - |
item.contributor | Costa, Francesco | - |
item.contributor | Adamo, Marianna | - |
item.contributor | Ariotti, Sara | - |
item.contributor | Ferrante, Giuseppe | - |
item.contributor | Navarese, Eliano Pio | - |
item.contributor | Leonardi, Sergio | - |
item.contributor | Garcia-Garcia, Hector | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Valgimigli, Marco | - |
crisitem.journal.issn | 1774-024X | - |
crisitem.journal.eissn | 1969-6213 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Left_main_or_proximal_left_anterior_desc.pdf Restricted Access | Published version | 1.13 MB | Adobe PDF | View/Open Request a copy |
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