Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/26528
Title: | From Bone Marrow to Cardiac Atrial Appendage Stem Cells for Cardiac Repair: A Review | Authors: | HENDRIKX, Marc FANTON, Yanick WILLEMS, Leen Daniels, Annick DECLERCQ, Jeroen WINDMOLDERS, Severina HENSEN, Karen KONINCKX, Remco Jamaer, Luc Dubois, Jasperina Dilling-Boer, Dagmara VANDEKERKHOF, Jos Hendrikx, Filip Bijnens, Eric Heuts, Nick ROBIC, Boris BITO, Virginie AMELOOT, Marcel STEELS, Paul RUMMENS, Jean-Luc |
Issue Date: | 2016 | Source: | CURRENT MEDICINAL CHEMISTRY, 23(23), p. 2421-2438 | Abstract: | Traditionally the heart is considered a terminally differentiated organ. However, at the beginning of this century increased mitotic activity was reported in ischemic and idiopathic dilated cardiomyopathy hearts, compared to healthy controls, underscoring the potential of regeneration after injury. Due to the presence of adult stem cells in bone marrow and their purported ability to differentiate into other cell lineages, this cell population was soon estimated to be the most suited candidate for cardiac regeneration. Clinical trials with autologous bone marrow-derived mononuclear cells, using either an intracoronary or direct intramyocardial injection approach consistently showed only minor improvement in global left ventricular ejection fraction. This was explained by their limited cardiomyogenic differentiation potential. To obtain more convincing improvement in cardiac function, based on true myocardial regeneration, the focus of research has shifted towards resident cardiac progenitor cells. Several isolation procedures have been described: the c-kit surface marker was the first to be used, however experimental research has clearly shown that c-kit+ cells only marginally contribute to regeneration post myocardial infarction. Sphere formation was used to isolate the so-called cardiosphere derived cells (CDC), and also in this cell population cardiomyogenic differentiation is a rare event. Recently a new type of stem cells derived from atrial tissue (cardiac atrial stem cells - CASCs) was identified, based on the presence of the enzyme aldehyde dehydrogenase (ALDH). Those cells significantly improve both regional and global LV ejection fraction, based on substantial engraftment and consistent differentiation into mature cardiomyocytes (98%). | Keywords: | cardiac stem cell; differentiation; magnetic resonance imaging; mapping; migration; mesenchymal stem cells; myocardial infarction; platelet derived growth factor | Document URI: | http://hdl.handle.net/1942/26528 | Link to publication/dataset: | https://www.researchgate.net/profile/Leen_Willems2/publication/303530870_From_Bone_Marrow_to_Cardiac_Atrial_Appendage_Stem_Cells_for_Cardiac_Repair_A_Review/links/5853a6c308ae7d33e01ae663/From-Bone-Marrow-to-Cardiac-Atrial-Appendage-Stem-Cells-for-Cardiac-Repair-A-Review.pdf?origin=publication_detail | ISSN: | 0929-8673 | e-ISSN: | 1875-533X | DOI: | 10.2174/0929867323666160525114735 | ISI #: | 000382264400002 | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s3.pdf Restricted Access | Published version | 4.7 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
1
checked on Apr 8, 2020
WEB OF SCIENCETM
Citations
7
checked on Oct 14, 2024
Page view(s)
90
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.