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Title: ECG Voltage in Relation to Peripheral and Central Ambulatory Blood Pressure
Authors: Yang, Wen-Yi
Mujaj, Blerim
Efremov, Ljupcho
Zhang, Zhen-Yu
Thijs, Lutgarde
Wei, Fang-Fei
Huang, Qi-Fang
Luttun, Aernout
Verhamme, Peter
Boggia, Jose
Staessen, Jan A.
Issue Date: 2018
Abstract: BACKGROUND The heart ejects in the central elastic arteries. No previous study in workers described the diurnal profile of central blood pressure (BP) or addressed the question whether electrocardiogram (ECG) indexes are more closely associated with central than peripheral BP. METHODS In 177 men (mean age, 29.1 years), we compared the associations of ECG indexes with brachial and central ambulatory BP, measured over 24 hours by the validated oscillometric Mobil-O-Graph 24h PWA monitor. RESULTS From wakefulness to sleep, as documented by diaries, systolic/diastolic BP decreased by 11.7/13.1 mm Hg peripherally and 9.3/13.6 mm Hg centrally, whereas central pulse pressure (PP) increased by 4.3 mm Hg (P < 0.0001). Over 24 hours and the awake and asleep periods, the peripheral-minus-central differences in systolic/diastolic BPs averaged 11.8/-1.6, 12.7/-1.8, and 10.3/-1.2 mm Hg, respectively (P < 0.0001). Cornell voltage and index averaged 1.18 mV and 114.8 Per 1-SD increment in systolic/diastolic BP, the Cornell voltages were 0.104/0.086 mV and 0.082/0.105 mV higher in relation to brachial 24-hour and asleep BP and 0.088/0.90 mV and 0.087/0.107 mV higher in relation to central BP. The corresponding estimates for the Cornell indexes were 9.6/8.6 and 8.2/10.5 peripherally and 8.6/8.9 and 8.8/10.7 centrally. The regression slopes (P = 0.067) and correlation coefficients (P = 0.088) were similar for brachial and central BP. Associations of ECG measurements with awake BP and PP were not significant. CONCLUSIONS Peripheral and central BPs run in parallel throughout the day and are similarly associated with the Cornell voltage and index.
Notes: [Yang, Wen-Yi; Mujaj, Blerim; Efremov, Ljupcho; Zhang, Zhen-Yu; Thijs, Lutgarde; Wei, Fang-Fei; Huang, Qi-Fang; Staessen, Jan A.] Univ Leuven, Fac Med, Studies Coordinating Ctr, KU Leuven Dept Cardiovasc Sci,Res Unit Hypertens, Leuven, Belgium. [Luttun, Aernout; Verhamme, Peter] Univ Leuven, Fac Med, Ctr Mol & Vasc Biol, KU Leuven Dept Cardiovasc Sci, Leuven, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Boggia, Jose] Univ Republica, Hosp Clin, Ctr Nefrol, Dept Fisiopatol,Unidad Hipertens Arterial, Montevideo, Uruguay. [Staessen, Jan A.] Maastricht Univ, R & D VitaK Grp, Maastricht, Netherlands.
Keywords: ambulatory blood pressure; blood pressure; blood pressure monitoring; central blood pressure; clinical science; ECG voltage; hypertension;ambulatory blood pressure; blood pressure; blood pressure monitoring; central blood pressure; clinical science; ECG voltage; hypertension
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ISSN: 0895-7061
e-ISSN: 1941-7225
DOI: 10.1093/ajh/hpx157
ISI #: 000422955700010
Rights: © The Author(s) 2017. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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