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http://hdl.handle.net/1942/26548
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DC Field | Value | Language |
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dc.contributor.author | VRIJENS, Karen | - |
dc.contributor.author | TSAMOU, Maria | - |
dc.contributor.author | MADHLOUM, Narjes | - |
dc.contributor.author | GYSELAERS, Wilfried | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2018-08-02T12:07:48Z | - |
dc.date.available | 2018-08-02T12:07:48Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | JOURNAL OF TRANSLATIONAL MEDICINE, 16 (Art N° 2) | - |
dc.identifier.issn | 1479-5876 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26548 | - |
dc.description.abstract | Background: HIF1 alpha, miR-210 and its downstream targets ISCU, COX-10, RAD52 and PTEN are all part of the placental hypoxia-responsive network. Tight regulation of this network is reguired to prevent development of maternal-fetal complications such as fetal growth restriction. HIF1 alpha expression is increased in preeclamptic placentae, but little is known about its association with birth weight in normal pregnancies. Methods: We measured placental levels of HIF1 alpha, miR-20a, miR-210, ISCU, COX-10, RAD52 and PTEN in 206 mother-newborn pairs of the ENVIRONAGE birth cohort. Results: Placental HIF1 alpha gene expression was inversely associated with the ponderal index (PI): for a doubling in placental HIF1 alpha expression, PI decreased by 6.7% (95% confidence interval [Cl] 1.3 to 12.0%, p = 0.01). Placental RAD52 expression also displayed an inverse association with PI, a doubling in gene expression was associated with a 6.2% (Cl 0.2 to 12.1% p = 0.04) decrease in PI. As for birth weight, we observed a significant association with placental miR-20a expression only in boys, where a doubling in miR-20a expression is associated with a 54.2 g (Cl 0.6 to 108 g, p = 0.05) increase in birth weight. Conclusions: The decrease in fetal growth associated with expression of hypoxia-network members HIF1 alpha, RAD52 and miR-20a indicates that this network is important in potential intrauterine insults. | - |
dc.description.sponsorship | The ENVIRONAGE birth cohort is supported by grants from the European Research Council (ERC-2012-StG 310898) and Flemish Research Council (FWO G073315N). Karen Vrijens is a postdoctoral fellow of the FWO (12D7714N). | - |
dc.language.iso | en | - |
dc.publisher | BIOMED CENTRAL LTD | - |
dc.rights | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.subject.other | Birth weight; Gene expression; HIF1 alpha; Hypoxia; Placenta | - |
dc.subject.other | birth weight; gene expression; HIF1 alpha; hypoxia; placenta | - |
dc.title | Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 16 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Vrijens, Karen; Tsamou, Maria; Madhloum, Narjes; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci Mol & Environm Epidemiol, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Gyselaers, Wilfried] East Limburg Hosp, Dept Obstet, B-3600 Genk, Belgium. [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth, Environm & Hlth Unit, KU Leuven, B-3000 Louvain, Belgium. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1186/s12967-017-1375-5 | - |
dc.identifier.isi | 000419907300001 | - |
item.fullcitation | VRIJENS, Karen; TSAMOU, Maria; MADHLOUM, Narjes; GYSELAERS, Wilfried & NAWROT, Tim (2018) Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study. In: JOURNAL OF TRANSLATIONAL MEDICINE, 16 (Art N° 2). | - |
item.contributor | VRIJENS, Karen | - |
item.contributor | TSAMOU, Maria | - |
item.contributor | MADHLOUM, Narjes | - |
item.contributor | GYSELAERS, Wilfried | - |
item.contributor | NAWROT, Tim | - |
item.validation | ecoom 2019 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.eissn | 1479-5876 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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vrijens 1.pdf | Published version | 1.04 MB | Adobe PDF | View/Open |
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