Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26558
Title: Prognostic Biomarkers in the Progression From MGUS to Multiple Myeloma: A Systematic Review
Authors: Cosemans, Charlotte 
Oben, Bénedith 
Arijs, Ingrid 
Daniels, Annick
Declercq, Jeroen
Vanhees, Kimberly 
Froyen, Guy 
Maes, Brigitte 
Mebis, Jeroen 
Rummens, Jean-Luc 
Issue Date: 2018
Source: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 18(4), p. 235-248
Abstract: Multiple myeloma (MM), characterized by malignant plasma cells in the bone marrow, is consistently preceded by asymptomatic premalignant stage monoclonal gammopathy of undetermined significance (MGUS). These MGUS patients have an annual risk of 1% to progress to MM. Clinical, imaging, and genomic (genetic and epigenetic) factors were identified, whose presence increased the risk of progression from MGUS to MM. In this systematic review we summarize the currently identified clinical, imaging, and genomic biomarkers suggested to increase the progression risk or shown to be differentially expressed/present between both cohorts of patients. Despite the wide range of proposed markers, there are still no reliable biomarkers to individually predict which MGUS patient will progress to MM and which will not. Research on biomarkers in the progression from MGUS to MM will give more insight in the unknown pathogenesis of this hematological malignancy. This would improve research by elucidating new pathways and potential therapeutic targets as well as clinical management by closer follow-up and earlier treatment of high-risk MGUS patients. (C) 2018 Elsevier Inc. All rights reserved.
Notes: Oben, B (reprint author), Stadsomvaart 11, B-3500 Hasselt, Belgium, benedith.oben@uhasselt.be
Keywords: biological marker; disease progression; hematological malignancy; premalignant stage; risk factors
Document URI: http://hdl.handle.net/1942/26558
ISSN: 2152-2650
e-ISSN: 2152-2669
DOI: 10.1016/j.clml.2018.02.011
ISI #: 000428862400005
Rights: (C) 2018 Elsevier Inc. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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