Please use this identifier to cite or link to this item:
Title: Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium
Authors: Cattoir, Lien
Van Hoecke, Frederik
Van Maerken, Tom
Nys, Eveline
Ryckaert, Inge
De Boulle, Matthias
Geerts, Anja
Verhelst, Xavier
Colle, Isabelle
Hutse, Veronik
Suin, Vanessa
Wautier, Magali
Van Gucht, Steven
Van Vlierberghe, Hans
PADALKO, Elizaveta 
Issue Date: 2018
Abstract: Background: Hepatitis E virus (HEV) infection is increasingly recognized as a cause of hepatitis in developed countries. A high HEV IgG seroprevalence in humans and pigs is reported as well as sporadic clinical cases of autochtonous HEV but there are currently no data available on the clinical burden of HEV in Belgium. Objectives: The objective of the current study was to evaluate the actual clinical burden of HEV infections in our tertiary care center in Flanders, Belgium. Study design: In the setting of Ghent University Hospital, patients were assessed for the presence of HEV IgG and IgM as well as HEV RNA if no other cause was found for one of the following clinical presentations: a) elevation of liver enzymes in post-liver transplant; b) suspicion of acute or toxic hepatitis; c) unexplainable elevation of liver enzymes; d) cirrhosis with acute-on-chronic exacerbation. Results: In a period of 39 months (January 2011-April 2014) 71 patients were enrolled. HEV IgG was found positive in 13 (18,3%) patients; HEV IgM in 6 patients (8,5%) and HEV RNA in 4 (5,6%) patients. All HEV IgM/ RNA positive patients were male, aged 41-63, and classified in the clinical groups a), b) or d). HEV IgG seroprevalence was slightly higher but not significantly different from the seroprevalence in the general population in this region in Belgium previously reported to be 14% (p-value 0.41) by our group. Conclusions: HEV should be considered as a cause of liver pathology especially in middle-aged men with elevation of liver enzymes.
Notes: Padalko, E (reprint author), De Pintelaan 185, B-9000 Ghent, Belgium.
Keywords: hepatitis E virus; clinical impact; Belgium
Document URI:
Link to publication:
ISSN: 1386-6532
e-ISSN: 1873-5967
DOI: 10.1016/j.jcv.2018.03.004
ISI #: 000432698300002
Rights: © 2018 Elsevier B.V. All rights reserved.
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

Files in This Item:
File Description SizeFormat 
cottoir 1.pdf
  Restricted Access
Published version154 kBAdobe PDFView/Open    Request a copy
cattoir2018.pdfPeer-reviewed author version306.23 kBAdobe PDFView/Open
Show full item record


checked on Sep 3, 2020


checked on May 22, 2022

Page view(s)

checked on May 24, 2022


checked on May 24, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.