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Title: Engineering the interface between lipid membranes and nanoporous gold: A study by quartz crystal microbalance with dissipation monitoring
Authors: LOSADA-PEREZ, Patricia 
Polat, Ozge
Parikh, Atul N.
Seker, Erkin
RENNER, Frank 
Issue Date: 2018
Source: BIOINTERPHASES, 13(1) (Art N° 011002)
Abstract: Nanoporous gold (np-Au) is a nanostructured metal with many desirable attributes. Despite the growing number of applications of nanoporous materials, there are still open questions regarding their fabrication and subsequent surface functionalization. For example, the hydrophobic nature of gold surfaces makes the formation of planar supported lipid layers challenging. Here, the authors engineer the interface between np-Au and 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid layers using well-differentiated approaches based on vesicle adsorption and solvent exchange methods. The results reveal that the nanotopography of the np-Au surface plays a clear role in the vesicle adsorption process. Compared to vesicle adsorption, the solvent exchange method proves successful in the formation of planar supported lipid bilayers in both np-Au and planar Au surfaces, being less sensitive to the surface morphological features. The influence of nanostructured surfaces on lipid layer formation is determined by the driving mechanisms behind each process, i.e., the balance of adhesion and cohesion forces in vesicle adsorption and lyotropic lipid phase transitions in solvent exchange, respectively. A better understanding of such interactions will contribute to the development of a variety of applications, from electrochemical biosensors to drug screening and delivery systems, using nanoporous gold coated with stimuli-responsive lipid layers. (C) 2017 Published by the AVS.
Notes: [Losada-Perez, Patricia; Renner, Frank Uwe] Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Polat, Ozge; Parikh, Atul N.] Univ Calif Davis, Dept Chem Engn, Davis, CA 95616 USA. [Seker, Erkin] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Renner, Frank Uwe] IMEC VZW, Div IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Losada-Perez, Patricia] Univ Libre Bruxelles, Soft Matter Phys Lab, Campus La Plaine,CP223,Blvd Triomphe, B-1050 Brussels, Belgium.
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ISSN: 1934-8630
e-ISSN: 1559-4106
DOI: 10.1116/1.5010249
ISI #: 000419391900001
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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