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http://hdl.handle.net/1942/26577
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DC Field | Value | Language |
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dc.contributor.author | Gargiulo, Giuseppe | - |
dc.contributor.author | Ariotti, Sara | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Leonardi, Sergio | - |
dc.contributor.author | Frigoli, Enrico | - |
dc.contributor.author | Ciociano, Nestor | - |
dc.contributor.author | Tumscitz, Carlo | - |
dc.contributor.author | Tomassini, Francesco | - |
dc.contributor.author | Calabro, Paolo | - |
dc.contributor.author | Garducci, Stefano | - |
dc.contributor.author | Crimi, Gabriele | - |
dc.contributor.author | Ando, Giuseppe | - |
dc.contributor.author | Ferrario, Maurizio | - |
dc.contributor.author | Limbruno, Ugo | - |
dc.contributor.author | Cortese, Bernardo | - |
dc.contributor.author | Sganzerla, Paolo | - |
dc.contributor.author | Lupi, Alessandro | - |
dc.contributor.author | Russo, Filippo | - |
dc.contributor.author | Garbo, Roberto | - |
dc.contributor.author | Ausiello, Arturo | - |
dc.contributor.author | Zavalloni, Dennis | - |
dc.contributor.author | Sardella, Gennaro | - |
dc.contributor.author | Esposito, Giovanni | - |
dc.contributor.author | Santarelli, Andrea | - |
dc.contributor.author | Tresoldi, Simone | - |
dc.contributor.author | Nazzaro, Marco Stefano | - |
dc.contributor.author | Zingarelli, Antonio | - |
dc.contributor.author | Petronio, Anna Sonia | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | da Costa, Bruno R. | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.date.accessioned | 2018-08-03T10:05:10Z | - |
dc.date.available | 2018-08-03T10:05:10Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | JACC-CARDIOVASCULAR INTERVENTIONS, 11(1), p. 36-50 | - |
dc.identifier.issn | 1936-8798 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26577 | - |
dc.description.abstract | OBJECTIVES This study sought to assess whether transradial access (TRA) compared with transfemoral access (TFA) is associated with consistent outcomes in male and female patients with acute coronary syndrome undergoing invasive management. BACKGROUND There are limited and contrasting data about sex disparities for the safety and efficacy of TRA versus TFA for coronary intervention. METHODS In the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) program, 8,404 patients were randomized to TRA or TFA. The 30-day coprimary outcomes were major adverse cardiovascular and cerebrovascular events (MACCE), defined as death, myocardial infarction, or stroke, and net adverse clinical events (NACE), defined as MACCE or major bleeding. RESULTS Among 8,404 patients, 2,232 (26.6%) were women and 6,172 (73.4%) were men. MACCE and NACE were not significantly different between men and women after adjustment, but women had higher risk of access site bleeding (male vs. female rate ratio [RR]: 0.64; p = 0.0016), severe bleeding (RR: 0.17; p = 0.0012), and transfusion (RR: 0.56; p = 0.0089). When comparing radial versus femoral, there was no significant interaction for MACCE and NACE stratified by sex (p(int) = 0.15 and 0.18, respectively), although for both coprimary endpoints the benefit with TRA was relatively greater in women (RR: 0.73; p = 0.019; and RR: 0.73; p = 0.012, respectively). Similarly, there was no significant interaction between male and female patients for the individual endpoints of all-cause death (p(int) = 0.79), myocardial infarction (p(int) = 0.25), stroke (p(int) = 0.18), and Bleeding Academic Research Consortium type 3 or 5 (p(int) = 0.45). CONCLUSIONS Women showed a higher risk of severe bleeding and access site complications, and radial access was an effective method to reduce these complications as well as composite ischemic and ischemic or bleeding endpoints. (C) 2018 by the American College of Cardiology Foundation. | - |
dc.description.sponsorship | The trial was sponsored by the Societa Italiana di Cardiologia Inasiva (a nonprofit organization), which received grant support from The Medicines Company and Terumo. This substudy did not receive any direct or indirect funding. Dr. Gargiulo has received research grant support from the Cardiopath PhD program and from the Societa Italiana di Cardiologia supported by MSD Italia-Merck Sharp and Dohme Corporation. Dr. Vranckx has received personal fees from Daiichi-Sankyo and Bayer Healthcare. Dr. Leonardi has received personal fees from The Medicines Company, AstraZeneca, Chiesi, outside the submitted work; and grant support from AstraZeneca outside the submitted work. Dr. Ando has received nonfinancial support from Terumo and Volcano-Phillips; and personal fees from Abbott, Bayer Healthcare Pharmaceuticals, AstraZeneca, and Daiichi-Sankyo. Dr. Cortese has received research grants from AB Medica, Abbott, St. Jude Medical, and Stentys; and personal fees from Abbott, AstraZeneca, Daiichi-Sankyo and Eli-Lilly, Stentys, all outside the submitted work. Dr. Petronio is consultant for Medtronic, Boston Scientific, and Abbott. Dr Windecker has received research grants to the institution from Bracco, Boston Scientific, and Terumo. Dr. Valgimigli has received research grant support from The Medicines Company, Terumo, and AstraZeneca; and personal fees from Terumo, St. Jude Vascular, and Abbott Vascular. Dr. Sonia has served as a consultant for Medtronic, Boston Scientific, and Abbott. Dr. Windecker has received institutional research grants from Abbott, Boston Scientific, Biotronik, Medtronic, Edwards Lifesciences, and St. Jude Medical. All other authors have reported that they have norelationships relevant to the contents of this paper to disclose. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | (C) 2018 BY THE AMERICAN COLLEGE OF CARDIOLOGY FOUNDATION | - |
dc.subject.other | acute coronary syndrome(s); female; femoral access; male; MATRIX; radial access | - |
dc.subject.other | acute coronary syndrome(s); female; femoral access; male; MATRIX; radial access | - |
dc.title | Impact of Sex on Comparative Outcomes of Radial Versus Femoral Access in Patients With Acute Coronary Syndromes Undergoing Invasive Management Data From the Randomized MATRIX-Access Trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 50 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 36 | - |
dc.identifier.volume | 11 | - |
local.format.pages | 15 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Gargiulo, Giuseppe; Ariotti, Sara; Frigoli, Enrico; Windecker, Stephan; da Costa, Bruno R.; Valgimigli, Marco] Bern Univ Hosp, Dept Cardiol, Bern, Switzerland. [Gargiulo, Giuseppe; Esposito, Giovanni] Federico II Univ Naples, Dept Adv Biomed Sci, Naples, Italy. [Vranckx, Pascal] Jessa Ziekenhuis, Hartcentrum Hasselt, Dept Cardiol & Crit Care Med, Hasselt, Belgium. [Vranckx, Pascal] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Leonardi, Sergio; Crimi, Gabriele; Ferrario, Maurizio] Fdn IRCCS, Policlin San Matteo, Dipartimento CardioToracoVasc, UOC Cardiol, Pavia, Italy. [Ciociano, Nestor] EUSTRATEGY Assoc, Forli, Italy. [Tumscitz, Carlo] Azienda Osped Univ Ferrara, Cardiol Unit, Cona, Italy. [Tomassini, Francesco] ASL Torino 3, Ospedali Riuniti Rivoli, Cardiol Unit, Turin, Italy. [Calabro, Paolo] Univ Campania Luigi Vanvitelli, Dept Cardiothorac Sci, Div Cardiol, Naples, Italy. [Garducci, Stefano] Struttura Complessa Cardiol ASST Vimercate, Desio, Italy. [Crimi, Gabriele] ASL3 Osped Villa Scassi, Dept Cardiol, Genoa, Italy. [Ando, Giuseppe] Univ Messina, Azienda Osped Univ Policlin Martino, Messina, Italy. [Limbruno, Ugo] Azienda USL Toscana Sudest, UO Cardiol, Grosseto, Italy. [Cortese, Bernardo] ASST Fatebenefratelli Sacco, Milan, Italy. [Cortese, Bernardo] Fdn Toscana Gabriele Monasterio, Pisa, Italy. [Sganzerla, Paolo] Osped Treviglio, ASST Bergamo Ovest, Bergamo, Italy. [Lupi, Alessandro] Univ Hosp Maggiore Carita, Cardiol Unit, Novara, Italy. [Russo, Filippo] St Anna Hosp, Cardiol Dept, Cardiovasc Intervent Unit, Como, Italy. [Garbo, Roberto] Osped San Giovanni Bosco, Intervent Cardiol Unit, Turin, Italy. [Ausiello, Arturo] Casa Cura Villa Verde, Taranto, Italy. [Zavalloni, Dennis] IRCCS, Humanitas Res Hosp, Rozzano, Italy. [Sardella, Gennaro] Sapienza Univ Rome, Policlin Umberto 1, Dept Cardiovasc, Resp,Nephrol Anesthesiol & Geriatr Sci, Rome, Italy. [Santarelli, Andrea] Infermi Hosp, Cardiovasc Dept, Rimini, Italy. [Tresoldi, Simone] AO Osped Desio, Cardiol Unit, Desio, Italy. [Nazzaro, Marco Stefano] San Camillo Forlanini, Intervent Cardiol Unit, Rome, Italy. [Zingarelli, Antonio] IRCCS AOU San Martino, Intervent Cardiol Unit, Genoa, Italy. [Petronio, Anna Sonia] Univ Pisa, Cardiothorac & Vasc Dept, Catheterisat Lab, Pisa, Italy. [da Costa, Bruno R.] Univ Bern, Inst Primary Hlth Care BIHAM, Bern, Switzerland. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jcin.2017.09.014 | - |
dc.identifier.isi | 000419122800009 | - |
item.fullcitation | Gargiulo, Giuseppe; Ariotti, Sara; VRANCKX, Pascal; Leonardi, Sergio; Frigoli, Enrico; Ciociano, Nestor; Tumscitz, Carlo; Tomassini, Francesco; Calabro, Paolo; Garducci, Stefano; Crimi, Gabriele; Ando, Giuseppe; Ferrario, Maurizio; Limbruno, Ugo; Cortese, Bernardo; Sganzerla, Paolo; Lupi, Alessandro; Russo, Filippo; Garbo, Roberto; Ausiello, Arturo; Zavalloni, Dennis; Sardella, Gennaro; Esposito, Giovanni; Santarelli, Andrea; Tresoldi, Simone; Nazzaro, Marco Stefano; Zingarelli, Antonio; Petronio, Anna Sonia; Windecker, Stephan; da Costa, Bruno R. & Valgimigli, Marco (2018) Impact of Sex on Comparative Outcomes of Radial Versus Femoral Access in Patients With Acute Coronary Syndromes Undergoing Invasive Management Data From the Randomized MATRIX-Access Trial. In: JACC-CARDIOVASCULAR INTERVENTIONS, 11(1), p. 36-50. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2019 | - |
item.contributor | Gargiulo, Giuseppe | - |
item.contributor | Ariotti, Sara | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Leonardi, Sergio | - |
item.contributor | Frigoli, Enrico | - |
item.contributor | Ciociano, Nestor | - |
item.contributor | Tumscitz, Carlo | - |
item.contributor | Tomassini, Francesco | - |
item.contributor | Calabro, Paolo | - |
item.contributor | Garducci, Stefano | - |
item.contributor | Crimi, Gabriele | - |
item.contributor | Ando, Giuseppe | - |
item.contributor | Ferrario, Maurizio | - |
item.contributor | Limbruno, Ugo | - |
item.contributor | Cortese, Bernardo | - |
item.contributor | Sganzerla, Paolo | - |
item.contributor | Lupi, Alessandro | - |
item.contributor | Russo, Filippo | - |
item.contributor | Garbo, Roberto | - |
item.contributor | Ausiello, Arturo | - |
item.contributor | Zavalloni, Dennis | - |
item.contributor | Sardella, Gennaro | - |
item.contributor | Esposito, Giovanni | - |
item.contributor | Santarelli, Andrea | - |
item.contributor | Tresoldi, Simone | - |
item.contributor | Nazzaro, Marco Stefano | - |
item.contributor | Zingarelli, Antonio | - |
item.contributor | Petronio, Anna Sonia | - |
item.contributor | Windecker, Stephan | - |
item.contributor | da Costa, Bruno R. | - |
item.contributor | Valgimigli, Marco | - |
crisitem.journal.issn | 1936-8798 | - |
crisitem.journal.eissn | 1876-7605 | - |
Appears in Collections: | Research publications |
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gargiulo2018.pdf Restricted Access | Published version | 1.38 MB | Adobe PDF | View/Open Request a copy |
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