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http://hdl.handle.net/1942/26589
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DC Field | Value | Language |
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dc.contributor.author | LEMOINE, Lieselotte | - |
dc.contributor.author | THIJSSEN, Elsy | - |
dc.contributor.author | NOBEN, Jean-Paul | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | CARLEER, Robert | - |
dc.contributor.author | VAN DER SPEETEN, Kurt | - |
dc.date.accessioned | 2018-08-06T08:50:53Z | - |
dc.date.available | 2018-08-06T08:50:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 152, p. 39-46 | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26589 | - |
dc.description.abstract | Oxaliplatin is a platinum (Pt)(1) containing antineoplastic agent that is applied in current clinical practice for the treatment of colon and appendiceal neoplasms. A fully validated, highly sensitive, high throughput inductively coupled plasma mass spectrometry (ICP-MS) method is provided to quantify the total Pt content in plasma, plasma ultrafiltrate, urine and peritoneal fluid. In this ICP-MS approach, the only step of sample preparation is a 1000-fold dilution in 0.5% nitric acid, allowing the analysis of 17 samples per hour. Detection of Pt was achieved over a linear range of 0.01-100 ng/mL. The limit of quantification was 18.0 ng/mL Pt in plasma, 8.0 ng/mL in ultrafiltrate and 6.1 ng/mL in urine and peritoneal fluid. The ICP-MS method was further validated for inter-and intraday precision and accuracy (<= 15%), recovery, robustness and stability. Short-term storage of the biofluids, for 14 days, can be performed at -4 degrees C, -24 degrees C and -80 degrees C. As to long-term stability, up to 5 months, storage at -80 degrees C is encouraged. Furthermore, a timeline assessing the total and unbound Pt fraction in plasma and ultrafiltrate over a period of 45 h is provided. Following an incubation period of 5 h at 37 degrees C, 19-21% of Pt was recovered in the ultrafiltrate, emphasizing the extensive and rapid binding of oxaliplatin-derived Pt to plasma proteins. The described method can easily be implemented in a routine setting for pharmacokinetic studies in patients treated with oxaliplatin-based hyperthermic intraperitoneal perioperative chemotherapy. (C) 2018 Elsevier B.V. All rights reserved. | - |
dc.description.sponsorship | The authors acknowledge the financial support from the Agency for Innovation by Science and Technology (IWT) in Brussels, Belgium. Lieselotte Lemoine and Kurt Van der Speeten are researchers for the Limburg Clinical Research Program (LCRP) UHassalt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital, Belgium. Erik Royackers for his contribution in the initial stages of conducting this research. Karel Haesevoets for making the graphical abstract. The Department of Laboratory Medicine at the Ziekenhuis Oost-Limburg for providing the different biofluids. Sanofi for providing access to the following clinical documents: DOH0088, SPP0111, PKM2983 (part 2), VAR3149 and PKM2983 (part 1). | - |
dc.language.iso | en | - |
dc.rights | (C) 2018 Elsevier B.V. All rights reserved. | - |
dc.subject.other | platinum; ICP-MS; plasma; plasma ultrafiltrate; urine; peritoneal fluid | - |
dc.title | A validated inductively coupled plasma mass spectrometry (ICP-MS) method for the quantification of total platinum content in plasma, plasma ultrafiltrate, urine and peritoneal fluid | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 46 | - |
dc.identifier.spage | 39 | - |
dc.identifier.volume | 152 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Lemoine, L (reprint author), Ziekenhuis Oost Limburg, Campus Sint Jan Schiepse Bos 6, B-3600 Genk, Belgium. lieselotte.lemoine@uhasselt.be; elsy.thijssen@uhasselt.be; jeanpaul.noben@uhasselt.be; peter.adriaensens@uhasselt.be; robert.carleer@uhasselt.be; kurt.vanderspeeten@zol.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.jpba.2018.01.033 | - |
dc.identifier.isi | 000428362000006 | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2019 | - |
item.fulltext | With Fulltext | - |
item.contributor | LEMOINE, Lieselotte | - |
item.contributor | THIJSSEN, Elsy | - |
item.contributor | NOBEN, Jean-Paul | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | CARLEER, Robert | - |
item.contributor | VAN DER SPEETEN, Kurt | - |
item.fullcitation | LEMOINE, Lieselotte; THIJSSEN, Elsy; NOBEN, Jean-Paul; ADRIAENSENS, Peter; CARLEER, Robert & VAN DER SPEETEN, Kurt (2018) A validated inductively coupled plasma mass spectrometry (ICP-MS) method for the quantification of total platinum content in plasma, plasma ultrafiltrate, urine and peritoneal fluid. In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 152, p. 39-46. | - |
crisitem.journal.issn | 0731-7085 | - |
crisitem.journal.eissn | 1873-264X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
lemoine 1.pdf Restricted Access | Published version | 798.78 kB | Adobe PDF | View/Open Request a copy |
Manuscript finaal.pdf | Peer-reviewed author version | 392.21 kB | Adobe PDF | View/Open |
Fig 1.tif | Supplementary material | 2.34 MB | TIFF | View/Open |
Fig 2.tif | Supplementary material | 1.96 MB | TIFF | View/Open |
Fig 3.tif | Supplementary material | 1.95 MB | TIFF | View/Open |
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