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http://hdl.handle.net/1942/2659
Title: | Adapting sample size calculations to repeated measurements in clinical trials | Authors: | LINDSEY, Patrick | Issue Date: | 2001 | Publisher: | CARFAX PUBLISHING | Source: | JOURNAL OF APPLIED STATISTICS, 28(1). p. 81-89 | Abstract: | Many of the repeated-measures sample size calculation methods presented in the literature are not suitable when: . . the different treatments are assumed to be equal on average at baseline time due to randomization, . and the experimenters are interested in a pre-specified difference to be detected after a specific time period. The method presented here has been developed for those cases where a multivariate normal distribution can reasonably be assumed. It is likelihood-based and has been designed to be flexible enough to handle repeated-measures models, including a non-linear change in time, and an arbitrary correlation structure. | Notes: | Limburgs Univ Ctr, Diepenbeek, Belgium.Lindsey, PJ, Limburgs Univ Ctr, Diepenbeek, Belgium. | Document URI: | http://hdl.handle.net/1942/2659 | ISSN: | 0266-4763 | e-ISSN: | 1360-0532 | ISI #: | 000165844500006 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2001 |
Appears in Collections: | Research publications |
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