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DC Field | Value | Language |
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dc.contributor.author | Guilbert, Ariane | - |
dc.contributor.author | COX, Bianca | - |
dc.contributor.author | Bruffaerts, Nicolas | - |
dc.contributor.author | Hoebeke, Lucie | - |
dc.contributor.author | Packeu, Ann | - |
dc.contributor.author | Hendrickx, Marijke | - |
dc.contributor.author | De Cremer, Koen | - |
dc.contributor.author | Bladt, Sandrine | - |
dc.contributor.author | Brasseur, Olivier | - |
dc.contributor.author | Van Nieuwenhuyse, An | - |
dc.date.accessioned | 2018-08-06T11:08:27Z | - |
dc.date.available | 2018-08-06T11:08:27Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ENVIRONMENTAL HEALTH, 17 (Art N° 35) | - |
dc.identifier.issn | 1476-069X | - |
dc.identifier.uri | http://hdl.handle.net/1942/26601 | - |
dc.description.abstract | Background: Outdoor pollen grain and fungal spore concentrations have been associated with severe asthma exacerbations at the population level. The specific impact of each taxon and the concomitant effect of air pollution on these symptoms have, however, still to be better characterized. This study aimed to investigate the short-term associations between ambient concentrations of various aeroallergens and hospitalizations related to asthma in the Brussels-Capital Region (Belgium), an area recording especially high rates of admissions. Methods: Based on administrative records of asthma hospitalizations and regular monitoring of 11 tree/herbaceous pollen taxa and 2 fungal spore taxa, daily time series analyses covering the 2008-2013 period were performed. Effects up to 6 days after exposure were captured by combining quasi-Poisson regression with distributed lag models, adjusting for seasonal and long-term trends, day of the week, public holidays, mean temperature and relative humidity. Effect modification by age and air pollution (PM, NO2, O-3) was tested. Results: A significant increase in asthma hospitalizations was observed for an interquartile range increase in grass (5.9%, 95% CI: 0.0, 12.0), birch (3.2%, 95% CI: 1.1, 5.3) and hornbeam (0.7%, 95% CI: 0.2, 1.3) pollen concentrations. For several taxa including grasses, an age modification effect was notable, the hospitalization risk tending to be higher in individuals younger than 60 years. Air pollutants impacted the relationships too: the risk appeared to be stronger for grass and birch pollen concentrations in case of high PM10 and O-3 concentrations respectively. Conclusions: These findings suggest that airborne grass, birch and hornbeam pollen are associated with severe asthma exacerbations in the Brussels region. These compounds appear to act in synergy with air pollution and to more specifically affect young and intermediate age groups. Most of these life-threatening events could theoretically be prevented with improved disease diagnosis/management and targeted communication actions. | - |
dc.description.sponsorship | This study was entirely funded by Brussels-Environment (BIM-IBGE). This organization was partly involved in the study design, the supervision of the research, data procurement and results interpretation. Bianca Cox is a postdoctoral fellow of the FWO (12Q0517N). | - |
dc.language.iso | en | - |
dc.rights | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.subject.other | asthma; hospitalization; pollen grain; fungal spore; air pollution; time series; distributed lag model | - |
dc.title | Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 17 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Guilbert, A (reprint author), Sci Inst Publ Hlth, Hlth & Environm Unit, Rue Juliette Wytsmanstr 14, B-1050 Brussels, Belgium. ariane.guilbert@wiv-isp.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 35 | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1186/s12940-018-0378-x | - |
dc.identifier.isi | 000429733700002 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2019 | - |
item.contributor | Guilbert, Ariane | - |
item.contributor | COX, Bianca | - |
item.contributor | Bruffaerts, Nicolas | - |
item.contributor | Hoebeke, Lucie | - |
item.contributor | Packeu, Ann | - |
item.contributor | Hendrickx, Marijke | - |
item.contributor | De Cremer, Koen | - |
item.contributor | Bladt, Sandrine | - |
item.contributor | Brasseur, Olivier | - |
item.contributor | Van Nieuwenhuyse, An | - |
item.fullcitation | Guilbert, Ariane; COX, Bianca; Bruffaerts, Nicolas; Hoebeke, Lucie; Packeu, Ann; Hendrickx, Marijke; De Cremer, Koen; Bladt, Sandrine; Brasseur, Olivier & Van Nieuwenhuyse, An (2018) Relationships between aeroallergen levels and hospital admissions for asthma in the Brussels-Capital Region: a daily time series analysis. In: ENVIRONMENTAL HEALTH, 17 (Art N° 35). | - |
crisitem.journal.eissn | 1476-069X | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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guilbert 1.pdf | Published version | 484.76 kB | Adobe PDF | View/Open |
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