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Title: | Gestational stress in mouse dams negatively affects gestation and postpartum hippocampal BDNF and P11 protein levels | Authors: | VANMIERLO, Tim DE VRY, Jochen NELISSEN, Ellis Sierksma, Annerieke Roumans, Nadia STEINBUSCH, Harry Wennogle, Lawrence P. van den Hove, Daniel Prickaerts, Jos |
Issue Date: | 2018 | Publisher: | ACADEMIC PRESS INC ELSEVIER SCIENCE | Source: | MOLECULAR AND CELLULAR NEUROSCIENCE, 88, p. 292-299 | Abstract: | Stress during pregnancy increases the risk to develop psychological disorders such as depression during pregnancy or in the postpartum period. According to the neurotrophin hypothesis of depression, the pathophysiology of depression is caused by reduced neurotrophic activity in the brain. However, most studies only focus on the molecular changes happening to the offspring upon gestational stress. To gain insight into the potential molecular changes happening in the stressed dams, C57B16/J mice were stressed during their first week of gestation. At 28 days postpartum, the hippocampus and nucleus accumbens core of the dams, two brain regions heavily implicated in depression, were evaluated using immunohistochemistry to detect changes in the neurotrophin system. Gestational stress decreased the weight of the dams, increased the chance for spontaneous abortion and increased the weight of offspring. Litter size, survival rates and sex distribution were not altered as a consequence of gestational stress. Hippocampal brain-derived neurotrophic factor (BDNF) decreased following exposure to stress during pregnancy. Hippocampal protein levels of p75(NTR), a low-affinity receptor for BDNF which can induce apoptosis, were increased following exposure to stress. Protein levels of p11, of which the expression is regulated by BDNF, were decreased in the hippocampus. No changes were found for TrkB immunostaining or apoptosis. Taken together, this shows that stress during pregnancy negatively affects the neurotrophin system in the hippocampus of the dams, thereby reducing hippocampal plasticity. These data confirm that gestational stress has a negative impact on pregnancy. | Notes: | [Vanmierlo, Tim; De Vry, Jochen; Nelissen, Ellis; Sierksma, Annerieke; Roumans, Nadia; Steinbusch, Harry W. M.; van den Hove, Daniel; Prickaerts, Jos] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, POB 616, NL-6200 MD Maastricht, Netherlands. [Vanmierlo, Tim] Hasselt Univ, BIOMED, Dept Immunol & Biochem, Hasselt, Belgium. [Wennogle, Lawrence P.] Intra Cellular Therapies Inc, 3960 Broadway, New York, NY 10032 USA. [Sierksma, Annerieke] Katholieke Univ Leuven, VIB Ctr Biol Dis, Lab Res Neurodegenerat Dis, Ctr Human Genet, Leuven, Belgium. [Roumans, Nadia] Maastricht Univ, Sch Nutr Toxicol & Metab, Dept Human Biol, Maastricht, Netherlands. | Keywords: | Neurotrophins; p75(NTR); TrkB; Depression; Nucleus accumbens; Plasticity;neurotrophins; p75(NTR); TrkB; depression; nucleus accumbens; plasticity | Document URI: | http://hdl.handle.net/1942/26603 | ISSN: | 1044-7431 | e-ISSN: | 1095-9327 | DOI: | 10.1016/j.mcn.2018.02.009 | ISI #: | 000431097300028 | Rights: | © 2018 Elsevier Inc. All rights reserved | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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