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Title: | Cord blood leptin and insulin levels in association with mitochondrial DNA content | Authors: | VRIENS, Annette PLUSQUIN, Michelle Baeyens, Willy BRUCKERS, Liesbeth Den Hond, Elly Loots, Ilse Nelen, Vera Schoeters, Greet JANSSEN, Bram NAWROT, Tim |
Issue Date: | 2018 | Source: | Journal of Translational Medicine, 16(224), p. 1-9 | Abstract: | Background: The developmental origins of health and disease theory states that a disturbance in the early life environment can contribute to disease risk in later life. Leptin and insulin are anorectic hormones involved in energy homeostasis and are crucial for foetal growth. Disturbances in the levels of these hormones contribute to obesity and diabetes. In adults, altered mitochondrial function is an important hallmark of metabolic disorders, including obesity and diabetes. However, the mitochondrial effects of early life metabolic variation are unexplored. We investigated whether there is an association between metabolic hormones and mitochondrial DNA (mtDNA) content in early life.Methods: The study included 236 newborns from the FLEHS III birth cohort, Flanders (Belgium). Relative mtDNA content of cord blood leukocytes was determined using quantitative PCR. Cord blood levels of leptin and insulin were determined using immunoassays. We studied the association between these metabolic hormones and mtDNA content using multiple linear regression models, while accounting for covariates and potential confounders.Results: Leptin and insulin levels were positively associated with cord blood mtDNA content. mtDNA content was respectively 4.49% (95% CI 1.15–7.93; p= 0.008) and 1.60% (95% CI 0.31–2.91; p= 0.02) higher for a interquartile range increase of respectively cord blood leptin and insulin levels. In a sensitivity analysis, we observed that insulin and leptin were independently associated to mtDNA content and that insulin was stronger associated to mtDNA content in boys than in girls.Conclusion: Neonatal metabolic hormones were associated with cord blood mtDNA content, which suggests that in early life the variation of mtDNA content might accommodate or reflect changes in the metabolic status. | Notes: | Nawrot, TS (reprint author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. tim.nawrot@uhasselt.be | Keywords: | neonates; metabolic programming; mitochondrial DNA content; metabolic hormones; insulin; leptin | Document URI: | http://hdl.handle.net/1942/26693 | e-ISSN: | 1479-5876 | DOI: | 10.1186/s12967-018-1599-z | ISI #: | 000442101300002 | Rights: | © The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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