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http://hdl.handle.net/1942/26765
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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | NAWROT, Tim | - |
dc.date.accessioned | 2018-10-01T15:01:14Z | - |
dc.date.available | 2018-10-01T15:01:14Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Toxicology letters, 298, pag. 42-52 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | http://hdl.handle.net/1942/26765 | - |
dc.description.abstract | Studies suggest that leukocyte telomere length is an index of systemic ageing. Here, we discuss telomere length as a marker of biological ageing in relation to residential landscape (greenness), residential air pollution and work-related exposures. Telomere lengths are memories of cumulative oxidative and inflammatory stress, and show to have inverse associations with the risk of non-communicable diseases. For this reason, telomeres are considered as markers of biological ageing. Studies at birth, in children, young adulthood, and elderly show that residential green space, lower traffic exposure and long-term lower exposure to particulate air pollution are associated with longer telomeres. Work-related exposures including exposure to toxic metals, polycyclic aromatic hydrocarbons and particulate matter are associated with shorter telomeres for a given age. In contrast to chronic exposures, evidence is present of the observation that recent exposure is associated with longer telomeres. Our overview shows that the magnitude of residential and work-related environmental factors on telomere length are often as important as many classical lifestyle factors. | - |
dc.description.sponsorship | This review is supported by grants from the European Research Council (ERC-2012-StG 310898) and Flemish Research Fund (FWO G073315N). | - |
dc.language.iso | en | - |
dc.rights | Copyright © 2018 Elsevier B.V. All rights reserved. | - |
dc.subject.other | telomeres; telomere length; air pollution; particulate matter; polycyclic aromatic hydrocarbons; residential greenness; toxic metals | - |
dc.title | Ageing at the level of telomeres in association to residential landscape and air pollution at home and work: a review of the current evidence | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 52 | - |
dc.identifier.spage | 42 | - |
dc.identifier.volume | 298 | - |
local.format.pages | 11 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Nawrot, TS (reprint author), Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. tim.nawrot@uhasselt.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.status | In press | - |
dc.identifier.doi | 10.1016/j.toxlet.2018.06.1213 | - |
dc.identifier.isi | 000450122200007 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2019 | - |
item.contributor | MARTENS, Dries | - |
item.contributor | NAWROT, Tim | - |
item.fullcitation | MARTENS, Dries & NAWROT, Tim (2018) Ageing at the level of telomeres in association to residential landscape and air pollution at home and work: a review of the current evidence. In: Toxicology letters, 298, pag. 42-52. | - |
crisitem.journal.issn | 0378-4274 | - |
crisitem.journal.eissn | 1879-3169 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S0378427418314528-main.pdf Restricted Access | Published version | 335.7 kB | Adobe PDF | View/Open Request a copy |
martens2018.pdf | Peer-reviewed author version | 498.15 kB | Adobe PDF | View/Open |
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