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http://hdl.handle.net/1942/2710
Title: | Foundations of the minimal clinically important difference for imaging | Authors: | Lassere, MND VAN DER HEIJDE, Desiree Johnson, KR |
Issue Date: | 2001 | Publisher: | J RHEUMATOL PUBL CO | Source: | JOURNAL OF RHEUMATOLOGY, 28(4). p. 890-891 | Abstract: | This article develops a generic conceptual framework for defining and validating the concept of minimal clinically important difference. We propose 3 approaches. The first uses statistical descriptions of the population ("distribution based"), the second relies on experts ("opinion based"), and a third is based on sequential hypothesis formation and testing ("predictive/data driven based"). The first 2 approaches serve as proxies for the third, which is an experimentally driven approach, asking such questions as "What carries the least penalty?" or "What imparts the greatest gain?" As an experimental approach, it has the expected drawbacks, including the need for greater resources, and the need to tolerate trial and error en route. compared to the other 2 models. | Notes: | St George Hosp, Dept Rheumatol, Sydney, NSW, Australia. Univ Hosp Maastricht, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium. US FDA, CDER, Rockville, MD 20857 USA.Lassere, MND, St George Hosp, Dept Rheumatol, Kogarah, NSW 2217, Australia. | Keywords: | smallest detectable difference; randomized controlled trials; minimum clinically important difference | Document URI: | http://hdl.handle.net/1942/2710 | Link to publication/dataset: | http://jrheum.com/abstracts/abstracts01/890.html | ISSN: | 0315-162X | e-ISSN: | 1499-2752 | ISI #: | 000167808600040 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2002 |
Appears in Collections: | Research publications |
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