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http://hdl.handle.net/1942/2711
Title: | Reliability of measures of disease activity and disease damage in rheumatoid arthritis: Implications for smallest detectable difference, minimal clinically important difference, and analysis of treatment effects in randomized controlled trials | Authors: | Lassere, MND VAN DER HEIJDE, Desiree Johnson, KR Boers, M Edmonds, J |
Issue Date: | 2001 | Publisher: | J RHEUMATOL PUBL CO | Source: | JOURNAL OF RHEUMATOLOGY, 28(4). p. 892-903 | Abstract: | We evaluate measurement properties of common rheumatoid arthritis (RA) assessments. Included are a comprehensive literature review and new data on the reliability and smallest detectable difference (SDD) for different classes of these measures. We found that certain common measures such as joint counts, pain, and patient global all had poor reliability and showed large SDD compared to multi-item measures of physical/psychological function or compared to radiographic measures. We discuss the implications of these findings on the use of composite endpoints such as the ACR20 or the EULAR responder index in RA clinical trials, particularly the introduction of misclassification bias that arises from differential measurement error, Finally, we consider generically how the concept of the SDD might or might not relate to the concept of the minimal clinically important difference. | Notes: | St George Hosp, Dept Rheumatol, Sydney, NSW, Australia. Univ Hosp Maastricht, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium. US FDA, CDER, Rockville, MD 20857 USA. VU Univ Hosp, Dept Clin Epidemiol, Amsterdam, Netherlands.Lassere, MND, St George Hosp, Dept Rheumatol, Kogarah, NSW 2217, Australia. | Keywords: | minimal clinically important difference; reliability; randomized controlled trials; articular assessment; health status; radiographs | Document URI: | http://hdl.handle.net/1942/2711 | Link to publication/dataset: | http://jrheum.com/abstracts/abstracts01/892.html | ISSN: | 0315-162X | e-ISSN: | 1499-2752 | ISI #: | 000167808600041 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2002 |
Appears in Collections: | Research publications |
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