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http://hdl.handle.net/1942/27131
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DC Field | Value | Language |
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dc.contributor.author | BERVOETS, Liene | - |
dc.contributor.author | MASSA, Guy | - |
dc.contributor.author | GUEDENS, Wanda | - |
dc.contributor.author | REEKMANS, Gunter | - |
dc.contributor.author | NOBEN, Jean-Paul | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.date.accessioned | 2018-10-10T07:41:45Z | - |
dc.date.available | 2018-10-10T07:41:45Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Future science OA, 4(6) (Art N° FSO310) | - |
dc.identifier.issn | 2056-5623 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27131 | - |
dc.description.abstract | Aim: To identify the plasma metabolic profile associated with childhood obesity and its metabolic phenotypes. Materials & methods: The plasma metabolic profile of 65 obese and 37 normal-weight children was obtained using proton NMR spectroscopy. NMR spectra were rationally divided into 110 integration regions, which reflect relative metabolite concentrations, and were used as statistical variables. Results: Obese children show increased levels of lipids, N-acetyl glycoproteins, and lactate, and decreased levels of several amino acids, α-ketoglutarate, glucose, citrate, and cholinated phospholipids as compared with normal-weight children. Metabolically healthy children show lower levels of lipids and lactate, and higher levels of several amino acids and cholinated phospholipids, as compared with unhealthy children. Conclusion: This study reveals new valuable findings in the field of metabolomics and childhood obesity. Although validation should be performed, the proof of principle looks promising and justifies a deeper investigation of the diagnostic possibilities of proton NMR metabolomics in follow-up studies. | - |
dc.description.sponsorship | The authors thank the Research Foundation Flanders (FWO-Vlaanderen) for the scientific research community project MULTIMAR (Multidisciplinary Magnetic Resonance). | - |
dc.language.iso | en | - |
dc.rights | This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecomm ons.org/licenses/by/4.0/ | - |
dc.subject.other | amino acids; childhood obesity; metabolically healthy obesity; metabolic syndrome; metabolomics; multivariate analysis; N-acetyl glycoproteins; NMR spectroscopy; obesity; phospholipids | - |
dc.title | Identification of metabolic phenotypes in childhood obesity by 1H NMR metabolomics of blood plasma | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 6 | - |
dc.identifier.volume | 4 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | FSO310 | - |
dc.identifier.doi | 10.4155/fsoa-2017-0146 | - |
dc.identifier.isi | 000444915900002 | - |
item.validation | vabb 2020 | - |
item.accessRights | Open Access | - |
item.fullcitation | BERVOETS, Liene; MASSA, Guy; GUEDENS, Wanda; REEKMANS, Gunter; NOBEN, Jean-Paul & ADRIAENSENS, Peter (2018) Identification of metabolic phenotypes in childhood obesity by 1H NMR metabolomics of blood plasma. In: Future science OA, 4(6) (Art N° FSO310). | - |
item.fulltext | With Fulltext | - |
item.contributor | BERVOETS, Liene | - |
item.contributor | MASSA, Guy | - |
item.contributor | GUEDENS, Wanda | - |
item.contributor | REEKMANS, Gunter | - |
item.contributor | NOBEN, Jean-Paul | - |
item.contributor | ADRIAENSENS, Peter | - |
crisitem.journal.issn | 2056-5623 | - |
crisitem.journal.eissn | 2056-5623 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Accepted_Future Science_2018_fsoa-2017-0146.pdf | Published version | 1.29 MB | Adobe PDF | View/Open |
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