Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/27335
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Catry, Boudewijn | - |
dc.contributor.author | Latour, Katrien | - |
dc.contributor.author | BRUYNDONCKX, Robin | - |
dc.contributor.author | Diba, Camellia | - |
dc.contributor.author | GEERDENS, Candida | - |
dc.contributor.author | Coenen, Samuel | - |
dc.date.accessioned | 2018-11-13T08:22:38Z | - |
dc.date.available | 2018-11-13T08:22:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 7 (Art N° 76) | - |
dc.identifier.issn | 2047-2994 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27335 | - |
dc.description.abstract | Background: Treatment duration, treatment interval, formulation and type of antimicrobial (antibiotic) are modifiable factors that will influence antimicrobial selection pressure. Currently, the impact of the route of administration on the occurrence of resistance in humans is unclear. Methods: In this retrospective multi-center cohort study, we assessed the impact of different variables on antimicrobial resistance (AMR) in pathogens isolated from the urinary tract in older adults. A generalized estimating equations (GEE) model was constructed using 7397 Escherichia coli (E. coli) isolates. Results: Resistance in E. coli was higher when more antibiotics had been prescribed before isolation of the sample, especially in women (significant interaction p = 0.0016) and up to nine preceding prescriptions it was lower for higher proportions of preceding parenteral prescriptions (significant interactions p = 0.0067). The laboratory identity, dying, and the time between prescription and sampling were important confounders (p < 0.001). Conclusions: Our model describing shows a dose-response relation between antibiotic use and AMR in E. coli isolated from urine samples of older adults, and, for the first time, that higher proportions of preceding parenteral prescriptions are significantly associated with lower probabilities of AMR, provided that the number of preceding prescriptions is not extremely high (>= 10 during the 1.5 year observation period; 93% of 5650 included patients). | - |
dc.description.sponsorship | This study (IARG) was supported by the Belgian National Council for the Promotion of Quality (Nationale Raad voor Kwaliteitspromotie; URL: http://www.riziv.fgov.be/nl/riziv/organen/Paginas/nrkp.aspx#.Wx9PtdUzapo). The funders had an initial advisory role in study design and data collection. | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.rights | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | - |
dc.subject.other | Route of administration; Drug resistance; Uropathogens; Elderly | - |
dc.subject.other | Route of administration; Drug resistance; Uropathogens; Elderly | - |
dc.title | Characteristics of the antibiotic regimen that affect antimicrobial resistance in urinary pathogens | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 7 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Catry, Boudewijn; Latour, Katrien] Sciensano, Healthcare Associated Infect & Antimicrobial Resi, Ruy Juliette Wytsmanstr 14, B-1050 Brussels, Belgium. [Latour, Katrien] Univ Leuven, Dept Publ Hlth & Primary Care, KU Leuven, Leuven, Belgium. [Bruyndonckx, Robin; Diba, Camellia; Geerdens, Candida] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, I BIOSTAT, Hasselt, Belgium. [Bruyndonckx, Robin; Coenen, Samuel] Univ Antwerp, Vaccine & Infect Dis Inst VAXINFECTIO, Lab Med Microbiol, Antwerp, Belgium. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 76 | - |
dc.identifier.doi | 10.1186/s13756-018-0368-3 | - |
dc.identifier.isi | 000436180100001 | - |
item.fullcitation | Catry, Boudewijn; Latour, Katrien; BRUYNDONCKX, Robin; Diba, Camellia; GEERDENS, Candida & Coenen, Samuel (2018) Characteristics of the antibiotic regimen that affect antimicrobial resistance in urinary pathogens. In: ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 7 (Art N° 76). | - |
item.contributor | Catry, Boudewijn | - |
item.contributor | Latour, Katrien | - |
item.contributor | BRUYNDONCKX, Robin | - |
item.contributor | Diba, Camellia | - |
item.contributor | GEERDENS, Candida | - |
item.contributor | Coenen, Samuel | - |
item.validation | ecoom 2019 | - |
item.accessRights | Open Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 2047-2994 | - |
crisitem.journal.eissn | 2047-2994 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
catry 1.pdf | Published version | 787.21 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
6
checked on Apr 30, 2024
Page view(s)
84
checked on Sep 7, 2022
Download(s)
102
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.