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http://hdl.handle.net/1942/27509
Title: | How Low Can You Go? Low Densities of Poly(ethylene glycol) Surfactants Attract Stealth Proteins | Authors: | SENECA, Senne Simon, Johanna Weber, Claudia Ghazaryan, Arthur ETHIRAJAN, Anitha Mailaender, Volker Morsbach, Svenja Landfester, Katharina |
Issue Date: | 2018 | Source: | MACROMOLECULAR BIOSCIENCE, 18(9) (Art N° 1800075) | Abstract: | It is now well-established that the surface chemistry and “stealth” surface functionalities such as poly(ethylene glycol) (PEG) chains of nanocarriers play an important role to decrease unspecific protein adsorption of opsonizing proteins, to increase the enrichment of specific stealth proteins, and to prolong the circulation times of the nanocarriers. At the same time, PEG chains are used to provide colloidal stability for the nanoparticles. However, it is not clear how the chain length and density influence the unspecific and specific protein adsorption keeping at the same time the stability of the nanoparticles in a biological environment. Therefore, this study aims at characterizing the protein adsorption patterns depending on PEG chain length and density to define limits for the amount of PEG needed for a stealth effect by selective protein adsorption as well as colloidal stability during cell experiments. PEG chains are introduced using the PEGylated Lutensol AT surfactants, which allow easy modification of the nanoparticle surface. These findings indicate that a specific enrichment of stealth proteins already occurs at low PEG concentrations; for the decrease of unspecific protein adsorption and finally the colloidal stability a full surface coverage is advised. | Keywords: | nanocarriers; poly(ethylene glycol); protein corona; stealth effect; surfactants | Document URI: | http://hdl.handle.net/1942/27509 | ISSN: | 1616-5187 | e-ISSN: | 1616-5195 | DOI: | 10.1002/mabi.201800075 | ISI #: | 000443689800001 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Macromolecular Bioscience.pdf Restricted Access | Published version | 1.64 MB | Adobe PDF | View/Open Request a copy |
Macromolecular Bioscience SI.pdf Restricted Access | Supplementary material | 1.26 MB | Adobe PDF | View/Open Request a copy |
Macromolecular Bioscience author version.pdf | Peer-reviewed author version | 1.07 MB | Adobe PDF | View/Open |
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