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http://hdl.handle.net/1942/27567
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DC Field | Value | Language |
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dc.contributor.author | RUBENS, Maarten | - |
dc.contributor.author | VRIJSEN, Jeroen | - |
dc.contributor.author | LAUN, Joachim | - |
dc.contributor.author | JUNKERS, Tanja | - |
dc.date.accessioned | 2019-01-10T14:36:36Z | - |
dc.date.available | 2019-01-10T14:36:36Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Angewandte Chemie (International ed. in English), 58 (10), p. 3183-3187 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27567 | - |
dc.description.abstract | A novel continuous flow system for automated high-throughput screening, autonomous optimization, and enhanced process control of polymerizations was developed. The computer-controlled platform comprises a flow reactor coupled to size exclusion chromatography (SEC). Molecular weight distributions are measured online and used by a machine-learning algorithm to self-optimize reactions towards a programmed molecular weight by dynamically varying reaction parameters (i.e. residence time, monomer concentration, and control agent/initiator concentration). The autonomous platform allows targeting of molecular weights in a reproducible manner with unprecedented accuracy (<2.5% deviation from pre-selected goal) for both thermal and light-induced reactions. For the first time, polymers with predefined molecular weights can be custom made under optimal reaction conditions in an automated, high-throughput flow synthesis approach with outstanding reproducibility. © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
dc.description.sponsorship | The authors are grateful to the Fonds Wetenschappelijk Onderzoek (FWO) for providing scholarships for M.R., J.H.V., and J.L. Funding from Monash University is also kindly acknowledged. | - |
dc.language.iso | en | - |
dc.title | Precise Polymer Synthesis by Autonomous Self-Optimizing Flow Reactors | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3187 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 3183 | - |
dc.identifier.volume | 58 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Junkers, T (reprint author), Hasselt Univ, Martelarenlaan 42, B-3500 Hasselt, Belgium. tanja.junkers@monash.edu | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/anie.201810384 | - |
dc.identifier.isi | 000459709300040 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | RUBENS, Maarten; VRIJSEN, Jeroen; LAUN, Joachim & JUNKERS, Tanja (2019) Precise Polymer Synthesis by Autonomous Self-Optimizing Flow Reactors. In: Angewandte Chemie (International ed. in English), 58 (10), p. 3183-3187. | - |
item.validation | ecoom 2020 | - |
item.contributor | RUBENS, Maarten | - |
item.contributor | VRIJSEN, Jeroen | - |
item.contributor | LAUN, Joachim | - |
item.contributor | JUNKERS, Tanja | - |
crisitem.journal.issn | 1433-7851 | - |
crisitem.journal.eissn | 1521-3773 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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Angew Chem Int Ed - 2018 - Rubens - Precise Polymer Synthesis by Autonomous Self‐Optimizing Flow Reactors.pdf Restricted Access | Published version | 812.32 kB | Adobe PDF | View/Open Request a copy |
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