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DC Field | Value | Language |
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dc.contributor.author | MARTENS, Pieter | - |
dc.contributor.author | VERBRUGGE, Frederik | - |
dc.contributor.author | BERTRAND, Philippe | - |
dc.contributor.author | Verhaert, David | - |
dc.contributor.author | VANDERVOORT, Pieter | - |
dc.contributor.author | DUPONT, Matthias | - |
dc.contributor.author | Tang, W. H. Wilson | - |
dc.contributor.author | Janssens, Stefan | - |
dc.contributor.author | MULLENS, Wilfried | - |
dc.date.accessioned | 2019-01-16T13:18:53Z | - |
dc.date.available | 2019-01-16T13:18:53Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | CIRCULATION-CARDIOVASCULAR IMAGING, 11(9), p. 1-10 (Art N° e007813) | - |
dc.identifier.issn | 1941-9651 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27586 | - |
dc.description.abstract | BACKGROUND: Acute and chronic effects of cardiac resynchronization therapy (CRT) on pulmonary pressures, right ventricular function, and ventricular-vascular coupling during exercise are insufficiently understood. Yet, these factors are strongly associated with functional status and outcome. METHODS AND RESULTS: Heart failure patients with reduced ejection fraction indicated for CRT were prospectively included to undergo exercise echocardiography simultaneously with cardiopulmonary exercise testing before (pre_CRI), 1 day after (post_CRI), and 6 months (post6_CRI) after CRT implant. Right ventricular-arterial coupling was assessed by the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (SPAP) ratio. A total of 31 heart failure patients with reduced ejection fraction (age=66 +/- 13 years) were prospectively included. CRT resulted in an immediate reduction in rest SPAP (pre_CRT=32 +/- 16 versus post_CRT=23 +/- 16 mm Hg; P=0.006) and rest effective regurgitant orifice (pre_CRT=0.32 +/- 0.1 versus post_CRT=0.18 +/- 0.2; P=0.001) without changes in exercise mitral regurgitation or exercise SPAP indexed for cardiac output. Six months after CRT, in parallel with left ventricular reverse remodeling and a reduction in exercise mitral regurgitation and exercise E/e' ratio, the exercise SPAP/cardiac output significantly improved (post_CRT=5.6 +/- 3.1 versus post6_CRT=4.3 +/- 2.9 mm Hg center dot L-1 center dot min(-1); P=0.039), which was also illustrated by a reduced slope of Delta SPAP/Delta cardiac output (post_CRT-5.2 +/- 3.7 versus post6_CRT=2.9 +/- 2.7 mm Hg center dot L-1 center dot min(-1); P=0.002). CRT did not result in an acute or chronic effect on TAPSE or TAPSE/SPAP ratio at rest. However, exercise revealed the presence of right ventricular-arterial uncoupling which was not affected by an acute CRT effect (P=0.396) but only improved by a chronic CRT effect (P<0.001; TAPSE/SPAP ratio: pre_CRT=0.39 +/- 0.6 mm/mm Hg; post_CRT=0.42 +/- 0.5 mm/mm Hg; post6_CRT=0.84 +/- 0.12 mm/mm Hg). Of all exercise echocardiography variables, the TAPSE/SPAP ratio demonstrated the strongest correlation with Vo(2) peak (r=0.475), VENco(2) (r=-0.585), and workload (r=0.476) during cardiopulmonary exercise testing (P<0.05 all). Multivariate predictors affecting exercise ventricular-arterial coupling after CRT included metrics of residual exercise mitral regurgitation and systolic and diastolic left ventricular function. CONCLUSIONS: Chronic CRT beneficially influences pulmonary pressures and right ventricular-arterial coupling during exercise, which strongly relates to functional status. These findings are mechanistically linked to reverse remodeling with improved interventricular dependence and reduction in exercise mitral regurgitation. | - |
dc.description.sponsorship | Dr Martens is supported by a doctoral fellowship by the Research Foundation-Flanders (Fonds Wetenschappelijk Onderzoek [FWO], grant number: 1127917N). Drs Martens and Mullens are researchers for the Limburg Clinical Research Program (LCRP) UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk (LSM), Hasselt University, Ziekenhuis Oost-Limburg, and Jessa Hospital. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject.other | cardiac resynchronization therapy; echocardiography; exercise test; heart failure; workload | - |
dc.subject.other | cardiac resynchronization therapy; echocardiography; exercise test; heart failure; workload | - |
dc.title | Effect of Cardiac Resynchronization Therapy on Exercise-Induced Pulmonary Hypertension and Right Ventricular-Arterial Coupling A Cardiopulmonary Exercise Testing Imaging Evaluation | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 10 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1 | - |
dc.identifier.volume | 11 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Martens, Pieter; Verbrugge, Frederik H.; Bertrand, Philippe B.; Verhaert, David; Vandervoort, Pieter; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Martens, Pieter] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Mullens, Wilfried] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Diepenbeek, Belgium. [Tang, W. H. Wilson] Cleveland Clin, Heart & Vasc Inst, Dept Cardiovasc Med, Cleveland, OH 44106 USA. [Janssens, Stefan] Univ Hosp Leuven UZ Leuven, Dept Cardiol, Leuven, Belgium. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e007813 | - |
dc.identifier.doi | 10.1161/CIRCIMAGING.118.007813 | - |
dc.identifier.isi | 000445062900007 | - |
item.fullcitation | MARTENS, Pieter; VERBRUGGE, Frederik; BERTRAND, Philippe; Verhaert, David; VANDERVOORT, Pieter; DUPONT, Matthias; Tang, W. H. Wilson; Janssens, Stefan & MULLENS, Wilfried (2018) Effect of Cardiac Resynchronization Therapy on Exercise-Induced Pulmonary Hypertension and Right Ventricular-Arterial Coupling A Cardiopulmonary Exercise Testing Imaging Evaluation. In: CIRCULATION-CARDIOVASCULAR IMAGING, 11(9), p. 1-10 (Art N° e007813). | - |
item.contributor | MARTENS, Pieter | - |
item.contributor | VERBRUGGE, Frederik | - |
item.contributor | BERTRAND, Philippe | - |
item.contributor | Verhaert, David | - |
item.contributor | VANDERVOORT, Pieter | - |
item.contributor | DUPONT, Matthias | - |
item.contributor | Tang, W. H. Wilson | - |
item.contributor | Janssens, Stefan | - |
item.contributor | MULLENS, Wilfried | - |
item.validation | ecoom 2019 | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1941-9651 | - |
crisitem.journal.eissn | 1942-0080 | - |
Appears in Collections: | Research publications |
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martens2018.pdf Restricted Access | Published version | 704.29 kB | Adobe PDF | View/Open Request a copy |
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