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http://hdl.handle.net/1942/27632
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DC Field | Value | Language |
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dc.contributor.author | Vaes, Anouk W. | - |
dc.contributor.author | SPRUIT, Martijn A. | - |
dc.contributor.author | THEUNIS, Jan | - |
dc.contributor.author | Wouters, Emiel F. M. | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.date.accessioned | 2019-01-23T13:49:01Z | - |
dc.date.available | 2019-01-23T13:49:01Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | RESPIRATORY MEDICINE, 142, p. 41-47 | - |
dc.identifier.issn | 0954-6111 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27632 | - |
dc.description.abstract | Background: Patients with COPD are frequently diagnosed with cardiovascular disease. Peripheral endothelial dysfunction is an underlying mechanism and can be used as an early marker of cardiovascular impairment. To date, little is known on the association between peripheral endothelial dysfunction, cardiovascular risk factors and measurements of exercise capacity in patients with COPD. Therefore, we aimed to determine the relation between endothelial function and patient characteristics, cardiovascular risk factors and (micro)vascular and functional performance in patient with CODP. Methods: Clinical and demographic data of patients with COPD were measured during routine pre-rehabilitation assessment. Cardiovascular risk factors, including blood pressure, ankle brachial index, arterial stiffness and retinal vessel widths were obtained. Peripheral endothelial function was measured using the EndoPAT-2000. Functional performance was assessed using cardiopulmonary exercise test, constant work rate test and six-minute walk test. Results: 40 patients with COPD completed the study protocol (65% males; mean age: 62.8 +/- 7.3 years; mean FEV1: 45.8 +/- 17.5 %pred). Peripheral endothelial dysfunction was observed in 55% of the patients. Patients with peripheral endothelial dysfunction had significantly worse aerobic exercise capacity and higher prevalence of cardiovascular risk factors. Stepwise multivariate regression models identified sex, systolic blood pressure and maximal aerobic capacity as independent correlates of peripheral endothelial function. After correction for sex, age and systolic blood pressure, there was a significant partial correlation between peripheral endothelial function and maximal aerobic capacity (R = 0.51, p = 0.004). Conclusion: Peripheral endothelial function was positively associated with maximal aerobic capacity, when correcting for sex, age and systolic blood pressure. Establishing peripheral endothelial dysfunction as a determinant of impaired aerobic capacity in COPD can be valuable for developing interventions aiming to improve aerobic capacity, and in turn cardiovascular health. | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO LTD | - |
dc.rights | © 2018 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Chronic obstructive pulmonary disease (COPD);Endothelial function; Vascular function; Exercise capacity; Cardiovascular diseases; Cardiovascular risk factors | - |
dc.subject.other | Chronic obstructive pulmonary disease (COPD); Endothelial function; Vascular function; Exercise capacity; Cardiovascular diseases; Cardiovascular risk factors | - |
dc.title | Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 47 | - |
dc.identifier.spage | 41 | - |
dc.identifier.volume | 142 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Vaes, Anouk W.; Spruit, Martijn A.; Wouters, Emiel F. M.] Ciro, Dept Res & Educ, Horn, Netherlands. [Vaes, Anouk W.; Theunis, Jan; De Boever, Patrick] Flemish Inst Technol Res VITO, Environm Risk & Hlth Unit, Mol, Belgium. [Spruit, Martijn A.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr, NUTR Sch Nutr & Translat Res Metab, Dept Resp Med, Maastricht, Netherlands. [Spruit, Martijn A.] Hasselt Univ, Fac Rehabil Sci, Rehabil Res Ctr, REVAL,BIOMED Biomed Res Inst, Diepenbeek, Belgium. [De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.rmed.2018.07.013 | - |
dc.identifier.isi | 000443001500007 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Vaes, Anouk W.; SPRUIT, Martijn A.; THEUNIS, Jan; Wouters, Emiel F. M. & DE BOEVER, Patrick (2018) Peripheral endothelial function is positively associated with maximal aerobic capacity in patients with chronic obstructive pulmonary disease. In: RESPIRATORY MEDICINE, 142, p. 41-47. | - |
item.validation | ecoom 2019 | - |
item.contributor | Vaes, Anouk W. | - |
item.contributor | SPRUIT, Martijn A. | - |
item.contributor | THEUNIS, Jan | - |
item.contributor | Wouters, Emiel F. M. | - |
item.contributor | DE BOEVER, Patrick | - |
crisitem.journal.issn | 0954-6111 | - |
crisitem.journal.eissn | 1532-3064 | - |
Appears in Collections: | Research publications |
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vaes 1.pdf Restricted Access | Published version | 282.12 kB | Adobe PDF | View/Open Request a copy |
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