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Title: | Assessment of Cortical Interruptions in the Finger Joints of Patients With Rheumatoid Arthritis Using HR-pQCT, Radiography, and MRI | Authors: | Peters, Michiel van Tubergen, Astrid Scharmga, Andrea Driessen, Annemariek van Rietbergen, Bert Loeffen, Daan Weijers, Rene GEUSENS, Piet VAN DEN BERGH, Joop |
Issue Date: | 2018 | Publisher: | WILEY | Source: | JOURNAL OF BONE AND MINERAL RESEARCH, 33(9), p. 1676-1685 | Abstract: | Small cortical interruptions may be the first sign of an erosion, and more interruptions can be found in patients with rheumatoid arthritis (RA) compared with healthy subjects. First, we compared the number and size of interruptions in patients with RA with healthy subjects using high-resolution peripheral quantitative CT (HR-pQCT). Second, we investigated the association between structural damage and inflammatory markers on conventional radiography (CR) and MRI with interruptions on HR-pQCT. Third, the added value of HR-pQCT over CR and MRI was investigated. The finger joints of 39 patients with RA and 38 healthy subjects were examined through CR, MRI, and HR-pQCT. CRs were scored using the Sharp/Van der Heijde method. MRI images were analyzed for the presence of erosions, bone marrow edema, and synovitis. HR-pQCT images were analyzed for the number, surface area, and volume of interruptions using a semiautomated algorithm. Descriptives were calculated and associations were tested using generalized estimating equations. Significantly more interruptions and both a larger surface area and the volume of interruptions were detected in the metacarpophalangeal joints of patients with RA compared with healthy subjects (median, 2.0, 1.42mm(2), and 0.48mm(3) versus 1.0, 0.69mm(2), and 0.23mm(3), respectively; all p<0.01). Findings on CR and MRI were significantly associated with more and larger interruptions on HR-pQCT (prevalence ratios [PRs] ranging from 1.03 to 7.74; all p<0.01) in all subjects, and were consistent in patients with RA alone. Having RA was significantly associated with more and larger interruptions on HR-pQCT (PRs, 2.33 to 5.39; all p<0.01), also after adjustment for findings on CR or MRI. More and larger cortical interruptions were found in the finger joints of patients with RA versus healthy subjects, also after adjustment for findings on CR or MRI, implying that HR-pQCT imaging may be of value in addition to CR and MRI for the evaluation of structural damage in patients with RA. (c) 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc. | Notes: | [Peters, Michiel; van Tubergen, Astrid; Scharmga, Andrea; Geusens, Piet; van den Bergh, Joop] Maastricht Univ, Med Ctr, Dept Internal Med, Div Rheumatol, POB 5800, NL-6202 AZ Maastricht, Netherlands. [Peters, Michiel; van Tubergen, Astrid; Scharmga, Andrea; Driessen, Annemariek; Geusens, Piet] Sch Publ Hlth & Primary Care, Res Sch CAPHRI, Maastricht, Netherlands. [Peters, Michiel; Scharmga, Andrea; Driessen, Annemariek; van den Bergh, Joop] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Driessen, Annemariek] Maastricht Univ, Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands. [van Rietbergen, Bert] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. [van Rietbergen, Bert] Maastricht Univ, Med Ctr, Dept Orthopaed Surg, Maastricht, Netherlands. [Loeffen, Daan; Weijers, Rene] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [Geusens, Piet; van den Bergh, Joop] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [van den Bergh, Joop] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands. | Keywords: | CORTICAL INTERRUPTIONS; RHEUMATOID ARTHRITIS; HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; BONE MICROARCHITECTURE; RADIOGRAPHY; MAGNETIC RESONANCE IMAGING;CORTICAL INTERRUPTIONS; RHEUMATOID ARTHRITIS; HIGH-RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; BONE MICROARCHITECTURE; RADIOGRAPHY; MAGNETIC RESONANCE IMAGING | Document URI: | http://hdl.handle.net/1942/27633 | ISSN: | 0884-0431 | e-ISSN: | 1523-4681 | DOI: | 10.1002/jbmr.3466 | ISI #: | 000443230400016 | Rights: | © 2018 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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