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Title: | Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations | Authors: | PADALKO, Elizaveta Lagrou, Katrien Delforge, Marie-Luce Jansens, Hilde Ectors, Nadine Pirnay, Jean-Paul Klykens, Johan Sokal, Etienne Muylle, Ludo Libois, Agnes Vanderkelen, Alain Verbeken, Gilbert Matthys, Conny Goossens, Dominique Hanssens, Geert Baltes, Muriel Beele, Hilde |
Issue Date: | 2018 | Publisher: | SPRINGER | Source: | CELL AND TISSUE BANKING, 19(4), p. 681-695 | Abstract: | This paper on the biological tests carried out on serum/plasma samples from donors of human body material (HBM) is the result of a project of the working Group of Superior Health Council of Belgium formed with experts in the field of HBM and infectious serology. Indeed, uncertainty about the interpretation of biological test results currently leads to the sometimes unjustified cancelling of planned donations or the rejection of harvested HBM, whilst more sophisticated diagnostic algorithms would still allow the use of organs or HBM that would otherwise have been rejected. NAT tests will not be discussed in this publication. In the first part some general aspects as the need for a formal agreement between the Tissue Establishment l and the laboratory responsible for the biological testing, but also some specifications regarding testing material, the choice of additional biological tests, and some general aspects concerning interpretation and reporting are discussed. In a second part, detailed information and recommendations concerning the interpretation are presented for each of the mandatory tests (human immunodeficiency virus, hepatitis B virus, hepatitis C virus and syphilis) is presented. A number of not mandatory, but regularly used optional serological tests (e.g. for the detection of antibodies to Toxoplasma gondii, Epstein-Barr virus, human T cell leukemia virus and cytomegalovirus) are also extensively discussed. Although the project was meant to provide clarification and recommendations concerning the Belgian legislation, the majority of recommendations are also applicable to testing of donors of tissues and cells in other (European) countries. | Notes: | [Padalko, Elizaveta; Matthys, Conny; Beele, Hilde] Univ Ghent, Dept Clin Chem Microbiol & Immunol, Univ Hosp, Pintelaan 185,2P8, B-9000 Ghent, Belgium. [Padalko, Elizaveta] Hasselt Univ, Sch Life Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Padalko, Elizaveta; Lagrou, Katrien; Delforge, Marie-Luce; Jansens, Hilde; Ectors, Nadine; Pirnay, Jean-Paul; Klykens, Johan; Sokal, Etienne; Muylle, Ludo; Libois, Agnes; Vanderkelen, Alain; Verbeken, Gilbert; Matthys, Conny; Goossens, Dominique; Hanssens, Geert; Baltes, Muriel; Beele, Hilde] Super Hlth Council Belgium, Working Grp Cells Tissues & Organs, Brussels, Belgium. [Lagrou, Katrien; Ectors, Nadine; Klykens, Johan] Katholieke Univ Leuven, Herestr 49, B-3000 Louvain, Belgium. [Lagrou, Katrien; Ectors, Nadine; Klykens, Johan] Univ Hosp Leuven, Herestr 49, B-3000 Louvain, Belgium. [Delforge, Marie-Luce] Univ Libre Bruxelles, Hop Erasme, Route Lennik 808, B-1070 Brussels, Belgium. [Jansens, Hilde; Muylle, Ludo] Antwerp Univ, Wilrijkstr 10, B-2650 Edegem, Belgium. [Jansens, Hilde; Muylle, Ludo] Antwerp Univ Hosp, Wilrijkstr 10, B-2650 Edegem, Belgium. [Pirnay, Jean-Paul; Vanderkelen, Alain; Verbeken, Gilbert] Queen Astrid Mil Hosp, Lab Mol & Cellular Technol, Bruynstr 1, B-1120 Brussels, Belgium. [Sokal, Etienne] Catholic Univ Louvain, Ctr Therapie Cellulaire, Clin Univ St Luc, 10 Av Hippocrate, B-1200 Brussels, Belgium. [Libois, Agnes] Univ Libre Bruxelles, CHU St Pierre, 322 Rue Haute, B-1000 Brussels, Belgium. | Keywords: | Reporting; Interpretation; Biological test; Donor of human body material;Reporting; Interpretation; Biological test; Donor of human body material | Document URI: | http://hdl.handle.net/1942/27673 | ISSN: | 1389-9333 | e-ISSN: | 1573-6814 | DOI: | 10.1007/s10561-018-9721-2 | ISI #: | 000452009800022 | Rights: | © The Author(s) 2018 corrected publication October 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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