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DC Field | Value | Language |
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dc.contributor.author | Rodriguez-Girondo, Mar | - |
dc.contributor.author | Salo, Perttu | - |
dc.contributor.author | BURZYKOWSKI, Tomasz | - |
dc.contributor.author | Perola, Markus | - |
dc.contributor.author | HOUWING-DUISTERMAAT, Jeanne | - |
dc.contributor.author | Mertens, Bart | - |
dc.date.accessioned | 2019-02-14T13:33:59Z | - |
dc.date.available | 2019-02-14T13:33:59Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ANNALS OF APPLIED STATISTICS, 12(3), p. 1655-1678 | - |
dc.identifier.issn | 1932-6157 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27752 | - |
dc.description.abstract | Enriching existing predictive models with new biomolecular markers is an important task in the new multi-omic era. Clinical studies increasingly include new sets of omic measurements which may prove their added value in terms of predictive performance. We introduce a two-step approach for the assessment of the added predictive ability of omic predictors, based on sequential double cross-validation and regularized regression models. We propose several performance indices to summarize the two-stage prediction procedure and a permutation test to formally assess the added predictive value of a second omic set of predictors over a primary omic source. The performance of the test is investigated through simulations. We illustrate the new method through the systematic assessment and comparison of the performance of transcriptomics and metabolomics sources in the prediction of body mass index (BMI) using longitudinal data from the Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study, a population-based cohort from Finland. | - |
dc.description.sponsorship | Work supported by Grant MIMOmics of the European Union's Seventh Framework Programme (FP7-Health-F5-2012) number 305280. The DILGOM transcriptomics dataset was funded by Sigrid Juselius Foundation and Yrjo Jahnsson Foundation. The DILGOM NMR metabolomic dataset was funded by Yrjo Jahnsson Foundation. | - |
dc.language.iso | en | - |
dc.publisher | INST MATHEMATICAL STATISTICS | - |
dc.subject.other | Added predictive ability; double cross-validation; regularized regression; multiple omics sets | - |
dc.subject.other | Added predictive ability; double cross-validation; regularized regression; multiple omics sets | - |
dc.title | Sequential double cross-validation for assessment of added predictive ability in high-dimensional omic applications | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1678 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 1655 | - |
dc.identifier.volume | 12 | - |
local.format.pages | 24 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Rodriguez-Girondo, Mar; Houwing-Duistermaat, Jeanine; Mertens, Bart] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Leiden, Netherlands. [Salo, Perttu; Perola, Markus] Natl Inst Hlth & Welf, Helsinki, Finland. [Burzykowski, Tomasz] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat BioStat, Hasselt, Belgium. [Houwing-Duistermaat, Jeanine] Univ Leeds, Dept Stat, Leeds, W Yorkshire, England. | - |
local.publisher.place | CLEVELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1214/17-AOAS1125 | - |
dc.identifier.isi | 000444259500012 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.validation | ecoom 2019 | - |
item.contributor | Rodriguez-Girondo, Mar | - |
item.contributor | Salo, Perttu | - |
item.contributor | BURZYKOWSKI, Tomasz | - |
item.contributor | Perola, Markus | - |
item.contributor | HOUWING-DUISTERMAAT, Jeanne | - |
item.contributor | Mertens, Bart | - |
item.fullcitation | Rodriguez-Girondo, Mar; Salo, Perttu; BURZYKOWSKI, Tomasz; Perola, Markus; HOUWING-DUISTERMAAT, Jeanne & Mertens, Bart (2018) Sequential double cross-validation for assessment of added predictive ability in high-dimensional omic applications. In: ANNALS OF APPLIED STATISTICS, 12(3), p. 1655-1678. | - |
crisitem.journal.issn | 1932-6157 | - |
crisitem.journal.eissn | 1941-7330 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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10.1214@17-AOAS1125.pdf Restricted Access | Published version | 976.83 kB | Adobe PDF | View/Open Request a copy |
AOAS1607-015R2A0.pdf | Peer-reviewed author version | 1.23 MB | Adobe PDF | View/Open |
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