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http://hdl.handle.net/1942/27806
Title: | Glutamine Addiction and Therapeutic Strategies in Lung Cancer | Authors: | VANHOVE, Karolien DERVEAUX, Elien GRAULUS, Geert-Jan MESOTTEN, Liesbet THOMEER, Michiel NOBEN, Jean-Paul GUEDENS, Wanda ADRIAENSENS, Peter |
Issue Date: | 2019 | Source: | International journal of molecular sciences (Print), 20 (2) (Art N° 252) | Abstract: | Lung cancer cells are well-documented to rewire their metabolism and energy production networks to support rapid survival and proliferation. This metabolic reorganization has been recognized as a hallmark of cancer. The increased uptake of glucose and the increased activity of the glycolytic pathway have been extensively described. However, over the past years, increasing evidence has shown that lung cancer cells also require glutamine to fulfill their metabolic needs. As a nitrogen source, glutamine contributes directly (or indirectly upon conversion to glutamate) to many anabolic processes in cancer, such as the biosynthesis of amino acids, nucleobases, and hexosamines. It plays also an important role in the redox homeostasis, and last but not least, upon conversion to α-ketoglutarate, glutamine is an energy and anaplerotic carbon source that replenishes tricarboxylic acid cycle intermediates. The latter is generally indicated as glutaminolysis. In this review, we explore the role of glutamine metabolism in lung cancer. Because lung cancer is the leading cause of cancer death with limited curative treatment options, we focus on the potential therapeutic approaches targeting the glutamine metabolism in cancer. | Notes: | Adriaensens, P (reprint author), Hasselt Univ, Inst Mat Res, Biomol Design Grp, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. karolien.vanhove@uhasselt.be; elien.derveaux@uhasselt.be; geertjan.graulus@uhasselt.be; liesbet.mesotten@zol.be; michiel.thomeer@uhasselt.be; jeanpaul.noben@uhasselt.be; wanda.guedens@uhasselt.be; peter.adriaensens@uhasselt.be | Keywords: | Lung cancer; metabolism; glutamine; glutaminolysis; pathways; targeted treatment | Document URI: | http://hdl.handle.net/1942/27806 | ISSN: | 1661-6596 | e-ISSN: | 1422-0067 | DOI: | 10.3390/ijms20020252 | ISI #: | 000459746500020 | Rights: | Copyright 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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