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http://hdl.handle.net/1942/27871
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DC Field | Value | Language |
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dc.contributor.author | SANCHEZ, Lizet | - |
dc.contributor.author | MUCHENE, Leacky | - |
dc.contributor.author | Lorenzo-Luaces, Patricia | - |
dc.contributor.author | Viada, Carmen | - |
dc.contributor.author | Rodriguez, Pedro C. | - |
dc.contributor.author | Alfonso, Sailyn | - |
dc.contributor.author | Crombet, Tania | - |
dc.contributor.author | Neninger, Elia | - |
dc.contributor.author | SHKEDY, Ziv | - |
dc.contributor.author | Lage, Agustin | - |
dc.date.accessioned | 2019-03-07T14:17:57Z | - |
dc.date.available | 2019-03-07T14:17:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | SEMINARS IN ONCOLOGY, 45(1-2), p. 52-57 | - |
dc.identifier.issn | 0093-7754 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27871 | - |
dc.description.abstract | Background: Progress in immunotherapy has revolutionized the treatment landscape for advanced lung cancer, with emerging evidence of patients experiencing long-term survivals. The goal of this study was to explore the existence of short- and long-term survival populations and to assess the effect of immunotherapy on them. Methods: Data from two randomized, multicenter, controlled clinical trials was used to evaluate the effect of two therapeutic vaccines (anti-idiotypic vaccine VAXIRA and anti-EGF vaccine CIMAVAX) on survival curves in advanced non-small cell lung cancer patients. Data were fitted to Kaplan-Meier, standard Weibull survival, and two-component Weibull mixture models. Bayesian Information Criterion was used for model selection. Results: VAXIRA did not modify, neither the fraction of patients with long-term survivals (0.18 in the control group v 0.19 with VAXIRA, P = .88), nor the median overall survival of the patients in the short-term survival subpopulation (6.8 v 7.8 months, P = .24). However, this vaccine showed great benefit for the patients belonging to the subpopulation of patients with long-term survival (33.8 v 76.6 months, P <.0001). CIMAVAX showed impact in the overall survival of both short- and long-term populations (6.8 v 8.8 months, P = .005 and 33.8 v 61.8 months, P = .007). It also increased the proportion of patients with long-term survival (from 0.18 to 0.28, P = .02). Conclusions: This study shows that therapeutic vaccines produce differential effects on short- and long-term survival populations and illustrates the application of advanced statistical methods to deal with the long-term evolution of patients with advanced lung cancer in the era of immunotherapy. (C) 2018 Elsevier Inc. All rights reserved. | - |
dc.description.sponsorship | This work was supported by a UICC International Cancer Technology Transfer Fellowship (grant no. 326329). | - |
dc.language.iso | en | - |
dc.publisher | W B SAUNDERS CO-ELSEVIER INC | - |
dc.rights | Copyright 2018 Elsevier Inc. All rights reserved. | - |
dc.subject.other | long-term survival; non–small cell lung cancer; immunotherapy; survival mixture models | - |
dc.subject.other | long-term survival; non-small cell lung cancer; immunotherapy; survival mixture models | - |
dc.title | Differential effects of two therapeutic cancer vaccines on short- and long-term survival populations among patients with advanced lung cancer | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 57 | - |
dc.identifier.issue | 1-2 | - |
dc.identifier.spage | 52 | - |
dc.identifier.volume | 45 | - |
local.format.pages | 6 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Sanchez, Lizet; Lorenzo-Luaces, Patricia; Viada, Carmen; Rodriguez, Pedro C.; Crombet, Tania; Lage, Agustin] Ctr Mol Immunol, Clin Res Div, Calle 216 Esq 15, Havana 11600, Cuba. [Muchene, Leacky; Shkedy, Ziv] Hasselt Univ, Ctr Stat, Hasselt, Belgium. [Alfonso, Sailyn] Celestino Hernandez Robau Hosp, Villa Clara, Cuba. [Neninger, Elia] Hermanos Ameijeiras Hosp, Havana, Cuba. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1053/j.seminoncol.2018.04.005 | - |
dc.identifier.isi | 000448095600007 | - |
item.accessRights | Open Access | - |
item.contributor | SANCHEZ, Lizet | - |
item.contributor | MUCHENE, Leacky | - |
item.contributor | Lorenzo-Luaces, Patricia | - |
item.contributor | Viada, Carmen | - |
item.contributor | Rodriguez, Pedro C. | - |
item.contributor | Alfonso, Sailyn | - |
item.contributor | Crombet, Tania | - |
item.contributor | Neninger, Elia | - |
item.contributor | SHKEDY, Ziv | - |
item.contributor | Lage, Agustin | - |
item.fullcitation | SANCHEZ, Lizet; MUCHENE, Leacky; Lorenzo-Luaces, Patricia; Viada, Carmen; Rodriguez, Pedro C.; Alfonso, Sailyn; Crombet, Tania; Neninger, Elia; SHKEDY, Ziv & Lage, Agustin (2018) Differential effects of two therapeutic cancer vaccines on short- and long-term survival populations among patients with advanced lung cancer. In: SEMINARS IN ONCOLOGY, 45(1-2), p. 52-57. | - |
item.validation | ecoom 2019 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0093-7754 | - |
crisitem.journal.eissn | 1532-8708 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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sanchez 1.pdf Restricted Access | Published version | 754.67 kB | Adobe PDF | View/Open Request a copy |
sanchez2018.pdf | Peer-reviewed author version | 735.13 kB | Adobe PDF | View/Open |
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