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Title: | One-year clinical and computed tomography follow-up after implantation of bioresorbable vascular scaffolds in patients with coronary chronic total occlusions | Authors: | MAEREMANS, Joren Verhaert, David Pereira, Bruno Frambach, Peter Van Mieghem, Carlos Barbato, Emanuele WILLEMS, Endry VROLIX, Mathias DENS, Jo |
Issue Date: | 2018 | Publisher: | WILEY | Source: | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 92(3), p. 488-496 | Abstract: | Objectives: To assess the safety and efficacy of everolimus-eluting bioresorbable scaffolds (BRS) in the treatment of chronic total occlusions (CTO) using noninvasive multislice computed tomography (MSCT) angiography at one-year follow-up. Background: Current evidence regarding the safety and efficacy of BRS for the percutaneous treatment of CTO is limited. Methods: Between September 2013 and January 2016, patients who received one or more ABSORB BRSs were included at three centers. MSCT (including quantitative analysis) and clinical follow-up were performed at one year. Results: Forty-one CTO patients were included. Mean age was 6011 years and the majority was male (83%). Average Japanese CTO (J-CTO) score was 0.9 +/- 0.9. Seventy-one BRS were implanted in total with, on average, 1.7 +/- 0.8 scaffolds/patient, and a total length of 43 +/- 20 mm and diameter of 3.1 +/- 0.4 mm. One noncardiac death took place. MSCT angiography was performed in 34 (83%) patients: all scaffolds were patent, except in one patient, in whom a patent target vessel was present on subsequent diagnostic angiography. MSCT quality was sufficient for quantitative analyses in 27 patients (46 scaffolds): median reference versus scaffold minimal lumen diameter and minimal lumen area were measured, and showed a small difference of 0.1 mm (-0.2-0.4) (lumen diameter stenosis = 3.0%) and 0.5 mm(2) (-1.0-2.0) (lumen area stenosis = 4.2%). Conclusions: The low number of events and high patency rate at 1 year are encouraging the further use of the ABSORB scaffold for CTOs with low J-CTO score. Noninvasive MSCT angiography is a valid tool to assess scaffold patency, although its image resolution limits the use for quantitative measurements. | Notes: | [Maeremans, Joren; Dens, Jo] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. [Maeremans, Joren; Verhaert, David; Vrolix, Mathias; Dens, Jo] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Pereira, Bruno; Frambach, Peter] Inst Chirurg Cardiaque & Cardiol Intervent, Dept Cardiol, Luxembourg, Luxembourg. [Van Mieghem, Carlos; Barbato, Emanuele] Onze Lieve Vrouw Hosp, Dept Cardiol, Aalst, Belgium. [Barbato, Emanuele] Univ Naples Federico II, Dept Adv Biomed Med, Naples, Italy. [Willems, Endry] Ziekenhuis Oost Limburg, Dept Radiol, Genk, Belgium. | Keywords: | coronary artery disease; imagingmultidetector CT; percutaneous coronary intervention; stentbioabsorbable;Coronary artery disease; imaging—multidetector CT; percutaneous coronary intervention; stent—bioabsorbable | Document URI: | http://hdl.handle.net/1942/27895 | ISSN: | 1522-1946 | e-ISSN: | 1522-726X | DOI: | 10.1002/ccd.27390 | ISI #: | 000447198600027 | Rights: | Copyright 2017 WileyPeriodicals,Inc | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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maeremans 1.pdf Restricted Access | Published version | 425.04 kB | Adobe PDF | View/Open Request a copy |
Manuscript_DENS_CCI_Revision.pdf | Peer-reviewed author version | 417.99 kB | Adobe PDF | View/Open |
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