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Title: | Hepatic schistosomiasis with massive splenomegaly: a case report and literature review | Authors: | Thijs, L. MESSIAEN, Peter VAN DER HILST, Jeroen Madoe, V. Melis, C. Van Eyken, P. Vanmoerkerke, Ignace Janssens, F. |
Issue Date: | 2018 | Publisher: | UNIV CATHOLIQUE LOUVAIN-UCL | Source: | ACTA GASTRO-ENTEROLOGICA BELGICA, 81(1), p. 93-96 | Abstract: | Schistosomiasis is a parasitic disease caused by Schistosoma species. Intestinal and hepatic schistosomiases are the most common forms of chronic disease. We describe a case of a 26-year old patient from Eritrea who was referred to our hospital with abdominal pain and diarrhea. The diagnosis of hepatosplenic schistosomiasis was made by liver biopsy and the patient was treated with praziquantel. Hepatic schistosomiasis is characterised by deposition of schistosomal eggs in the liver which results in a host cell immune response and leads to granuloma formation and neoangiogenesis. This is hallmarked by different grades of periportal fibrosis with portal hypertension leading to splenomegaly. Normal liver architecture is preserved and periportal fibrosis can be reversible if treated adequately and timely. With a recent native schistosomiasis cluster report from France and the expected influx to Europe of persons from regions endemic for schistosomiasis, increased awareness of this disease in healthcare practitioners is needed. We review the epidemiology, pathogenesis, clinical presentation and treatment of schistosomiasis. | Notes: | [Thijs, L.; Vanmoerkerke, I.; Janssens, F.] Jessa Ziekenhuis Hasselt, Dept Gastroenterol & Hepatol, Salvatorstr 20, B-3500 Hasselt, Belgium. [Messiaen, P.; van der Hilst, J.] Jessa Ziekenhuis Hasselt, Dept Infect Dis & Immun, Hasselt, Belgium. [Messiaen, P.; van der Hilst, J.] Hasselt Univ, BIOMED Res Inst, Hasselt, Belgium. [Thijs, L.; Madoe, V.] Jessa Ziekenhuis Hasselt, Dept Haematol, Hasselt, Belgium. [Melis, C.; Van Eyken, P.] Ziekenhuis Oost Limburg Genk, Dept Pathol Anat, Genk, Belgium. | Keywords: | Schistosoma; S. mansoni; hepatic fibrosis; splenomegaly;Schistosoma; S. mansoni; hepatic fibrosis; splenomegaly | Document URI: | http://hdl.handle.net/1942/27905 | ISSN: | 1784-3227 | e-ISSN: | 1784-3227 | ISI #: | 000447226500013 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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