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http://hdl.handle.net/1942/27918
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DC Field | Value | Language |
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dc.contributor.author | King, Brad | - |
dc.contributor.author | Van Ruitenbeek, Peter | - |
dc.contributor.author | Leunissen, Inge | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | Heise, Kirstin | - |
dc.contributor.author | Santos Monteiro, Thiago | - |
dc.contributor.author | Hermans, Lize | - |
dc.contributor.author | Levin, Oron | - |
dc.contributor.author | Albouy, Genevieve | - |
dc.contributor.author | Mantini, Dante | - |
dc.contributor.author | Swinnen, Stephan | - |
dc.date.accessioned | 2019-03-18T13:51:57Z | - |
dc.date.available | 2019-03-18T13:51:57Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | CEREBRAL CORTEX, 28 (12), p. 4390-4402 | - |
dc.identifier.issn | 1047-3211 | - |
dc.identifier.uri | http://hdl.handle.net/1942/27918 | - |
dc.description.abstract | Aging is typically associated with substantial declines in motor functioning as well as robust changes in the functional organization of brain networks. Previous research has investigated the link between these 2 age-varying factors but examinations were predominantly limited to the functional organization within motor-related brain networks. Little is known about the relationship between age-related behavioral impairments and changes in functional organization at the whole brain (i.e., multiple network) level. This knowledge gap is surprising given that the decreased segregation of brain networks (i.e., increased internetwork connectivity) can be considered a hallmark of the aging process. Accordingly, we investigated the association between declines in motor performance across the adult lifespan (20–75 years) and age-related modulations of functional connectivity within and between resting state networks. Results indicated that stronger internetwork resting state connectivity observed as a function of age was significantly related to worse motor performance. Moreover, performance had a significantly stronger association with the strength of internetwork as compared with intranetwork connectivity, including connectivity within motor networks. These findings suggest that age-related declines in motor performance may be attributed to a breakdown in the functional organization of large-scale brain networks rather than simply age-related connectivity changes within motor-related networks. | - |
dc.description.sponsorship | KU Leuven Special Research Fund (grant C16/15/070 awarded to S.P.S. and D.M.) as well as from grants from the Research Foundation-Flanders (FWO; G.0708.14) and the Francqui Foundation. European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement (No. 703490) and a postdoctoral fellowship from the Research Foundation-Flanders (FWO; No 132635) to B.R.K. Wellcome Trust (grant 101253/A/13/Z to D.M.). | - |
dc.language.iso | en | - |
dc.rights | Copyright The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com | - |
dc.subject.other | aging; bimanual; functional connectivity; motor performance; resting state | - |
dc.title | Age-related declines in motor performance are associated with decreased segregation of large-scale resting state brain networks. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 4402 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 4390 | - |
dc.identifier.volume | 28 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Swinnen, SP (reprint author), Katholieke Univ Leuven, Movement Control & Neuroplastic Res Grp, Motor Control Lab, Tervuurse Vest 101, B-3001 Leuven, Belgium. Stephan.Swinnen@kuleuven.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1093/cercor/bhx297 | - |
dc.identifier.isi | 000452747500020 | - |
item.fulltext | With Fulltext | - |
item.contributor | King, Brad | - |
item.contributor | Van Ruitenbeek, Peter | - |
item.contributor | Leunissen, Inge | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | Heise, Kirstin | - |
item.contributor | Santos Monteiro, Thiago | - |
item.contributor | Hermans, Lize | - |
item.contributor | Levin, Oron | - |
item.contributor | Albouy, Genevieve | - |
item.contributor | Mantini, Dante | - |
item.contributor | Swinnen, Stephan | - |
item.validation | ecoom 2019 | - |
item.fullcitation | King, Brad; Van Ruitenbeek, Peter; Leunissen, Inge; CUYPERS, Koen; Heise, Kirstin; Santos Monteiro, Thiago; Hermans, Lize; Levin, Oron; Albouy, Genevieve; Mantini, Dante & Swinnen, Stephan (2018) Age-related declines in motor performance are associated with decreased segregation of large-scale resting state brain networks.. In: CEREBRAL CORTEX, 28 (12), p. 4390-4402. | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1047-3211 | - |
crisitem.journal.eissn | 1460-2199 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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oup-accepted-manuscript-2017.pdf Restricted Access | Published version | 923.62 kB | Adobe PDF | View/Open Request a copy |
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