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Title: The effects of fetal and perinatal asphyxia on neuronal cytokine levels and ceramide metabolism in adulthood
Authors: Vlassaks, Evi
Gavilanes, Antonio W. D.
Vles, Johan S. H.
Kramer, Boris W.
Strackx, Eveline
Martinez-Martinez, Pilar
Issue Date: 2013
Source: Journal of neuroimmunology, 255(1-2), p. 97-101
Abstract: In a rat model of global fetal and perinatal asphyxia, we investigated if asphyxia and long-lasting brain tolerance to asphyxia (preconditioning) are mediated by modifications in inflammatory cytokines and ceramide metabolism genes in prefrontal cortex, hippocampus and caudate-putamen at the age of 8 months. Most significant changes were found in prefrontal cortex, with reduced LAG1 homolog ceramide synthase I expression after both types of asphyxia. Additionally, sphingosine kinase 1 was upregulated in those animals that experienced the combination of fetal and perinatal asphyxia (preconditioning), suggesting increased cell proliferation. While cytokine levels are normal, levels of ceramide genes were modulated both after fetal and perinatal asphyxia in the adult prefrontal cortex. Moreover, the combination of two subsequent asphyctic insults provides long-lasting neuroprotection in the prefrontal cortex probably by maintaining normal apoptosis and promoting cell proliferation. Better understanding of the effects of asphyxia on ceramide metabolism will help to understand the changes leading to brain tolerance and will open opportunities for the development of new neuroprotective therapies. (C) 2012 Elsevier B.V. All rights reserved.
Notes: [Vlassaks, Evi; Gavilanes, Antonio W. D.; Vles, Johan S. H.; Deville, Sarah; Kramer, Boris W.; Strackx, Eveline; Martinez-Martinez, Pilar] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNS, Dept Neuropsychol, Div Neurosci, NL-6200 MD Maastricht, Netherlands. [Vlassaks, Evi; Gavilanes, Antonio W. D.; Kramer, Boris W.; Strackx, Eveline] Maastricht Univ, Med Ctr, Dept Pediat, Div Neonatol, NL-6202 AZ Maastricht, Netherlands. [Vlassaks, Evi; Vles, Johan S. H.; Kramer, Boris W.] Maastricht Univ, Sch Oncol & Dev Biol Maastricht GROW, NL-6202 AZ Maastricht, Netherlands. [Vles, Johan S. H.] Maastricht Univ, Med Ctr, NL-6202 AZ Maastricht, Netherlands.
Keywords: Ceramides; Neuroinflammation; Perinatal asphyxia; Preconditioning;Ceramides; Neuroinflammation; Perinatal asphyxia; Preconditioning
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ISSN: 0165-5728
e-ISSN: 1872-8421
DOI: 10.1016/j.jneuroim.2012.09.011
ISI #: 000315014700014
Rights: Copyright 2012 Elsevier B.V. All rights reserved.
Category: A1
Type: Journal Contribution
Appears in Collections:Research publications

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