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http://hdl.handle.net/1942/28138
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DC Field | Value | Language |
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dc.contributor.author | PEETERS, Toon | - |
dc.contributor.author | Penders, John | - |
dc.contributor.author | Smeekens, Sanne P. | - |
dc.contributor.author | Galazzo, Gianluca | - |
dc.contributor.author | HOUBEN, Bert | - |
dc.contributor.author | Netea, Mihai G | - |
dc.contributor.author | Savelkoul Paul H | - |
dc.contributor.author | GYSSENS, Inge | - |
dc.date.accessioned | 2019-05-06T08:34:15Z | - |
dc.date.available | 2019-05-06T08:34:15Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Future Microbiology, 14 (2), p. 111-127 | - |
dc.identifier.issn | 1746-0913 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28138 | - |
dc.description.abstract | Aim: We aimed to study the mucosal microbiota of the appendix in a prospective appendicitis cohort and to compare the fecal microbiota of patients and controls. We hypothesized that the microbiota may be associated with susceptibility to appendicitis. Patients & methods: The fecal microbiota of 99 patients and 106 controls were characterized using 16S–23S intergenic spacer profiling. Richness, diversity and community structure were compared. The appendiceal microbiota from 90 patients was analyzed according to the severity of appendicitis. Results: Overall fecal microbial richness and diversity were similar in patients and controls, yet richness and diversity within the group of Firmicutes, Actinobacteria, Fusobacteria and Verrucomicrobia phyla were lower in patients. Discriminant analyses could correctly classify patients and controls with fair accuracy. No differences were found according to severity in appendiceal or fecal microbiota. Conclusion: This study demonstrates differences in the composition of intestinal microbiota of appendicitis patients and healthy individuals. | - |
dc.description.sponsorship | This study is a part of the Limburg Clinical Research Program, UHasselt-ZOL-Jessa, supported by the foundation Limburg Sterk Merk, province of Limburg, Flemish government, Hasselt University, Ziekenhuis Oost-Limburg and Jessa Hospital. The study was supported by ESCMID Study Group on Molecular Diagnostics research (grant number #9334). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | - |
dc.language.iso | en | - |
dc.publisher | FUTURE MEDICINE LTD | - |
dc.subject.other | acute appendicitis | - |
dc.subject.other | adult population | - |
dc.subject.other | dysbiosis | - |
dc.subject.other | intestinal microbiota | - |
dc.subject.other | microbiome | - |
dc.subject.other | prospective cohort study | - |
dc.title | The fecal and mucosal microbiome in acute appendicitis patients: an observational study. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 127 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 111 | - |
dc.identifier.volume | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Peeters, T; Gyssens, IC (reprint author), Jessa Hosp, Dept Infect Dis & Immun, Hasselt, Belgium. Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands. Radboud Univ Nijmegen, Med Ctr, Radboudumc Ctr Infect Dis RCI, Nijmegen, Netherlands. toon.peeters@uhasselt.be; inge.gyssens@radboudumc.nl | - |
local.publisher.place | UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON N3 1QB, ENGLAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.2217/fmb-2018-0203 | - |
dc.identifier.isi | 000460351700005 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pubmed/30663346 | - |
dc.identifier.eissn | 1746-0921 | - |
local.uhasselt.international | yes | - |
item.contributor | PEETERS, Toon | - |
item.contributor | Penders, John | - |
item.contributor | Smeekens, Sanne P. | - |
item.contributor | Galazzo, Gianluca | - |
item.contributor | HOUBEN, Bert | - |
item.contributor | Netea, Mihai G | - |
item.contributor | Savelkoul Paul H | - |
item.contributor | GYSSENS, Inge | - |
item.fullcitation | PEETERS, Toon; Penders, John; Smeekens, Sanne P.; Galazzo, Gianluca; HOUBEN, Bert; Netea, Mihai G; Savelkoul Paul H & GYSSENS, Inge (2019) The fecal and mucosal microbiome in acute appendicitis patients: an observational study.. In: Future Microbiology, 14 (2), p. 111-127. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1746-0913 | - |
crisitem.journal.eissn | 1746-0921 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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fmb-2018-0203.pdf Restricted Access | Early view | 3.43 MB | Adobe PDF | View/Open Request a copy |
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