Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28141
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dc.contributor.authorTran, Thao Anh-
dc.contributor.authorGENTILE, Luca-
dc.date.accessioned2019-05-06T09:22:30Z-
dc.date.available2019-05-06T09:22:30Z-
dc.date.issued2018-
dc.identifier.citationSEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 87 (SI), p. 22-29-
dc.identifier.issn1084-9521-
dc.identifier.urihttp://hdl.handle.net/1942/28141-
dc.description.abstractInplanarians,pluripotencycanbestudiedinvivointheadultanimal,makingtheseanimalsauniquemodelsystemwherepluripotency-basedregeneration(PBR)—anditstherapeuticpotential—canbeinves-tigated.Thisreviewfocusesonrecentfindingstobuildacloudmodeloffaterestrictionlikelihoodforplanarianstemandprogenitorcells.Recently,acomputationalapproachbasedonfunctionalandmolec-ularprofilingatthesinglecelllevelwasproposedforhumanhematopoieticstemcells.Basedondatageneratedbothinvivoandexvivo,wehypothesizedthatplanarianstemcellscouldacquiremultipledirec-tionlineagebiases,followinga“badlands”landscape.Insteadofadiscretetree-likehierarchy,wherethepotencyofstem/progenitorcellsreducesstepwise,weproposeaContinuumofLOw-primedUnDiffer-entiatedPlanarianStem/ProgenitorCells(CLOUD-PSPCs).Everysubclassofneoblast/progenitorcellsisacloudoflikelihood,asthesinglecelltranscriptomicsdataindicate.TheCLOUD-HSPCsconceptwassubstantiatedbyinvitrodatafromcellculture;therefore,toconfirmtheCLOUD-PSPCsmodel,thepla-nariancommunityneedstodevelopnewtools,likelivecelltracking.FuturestudieswillallowadeeperunderstandingofPBRinplanarian,andthepossibleimplicationsforregenerativetherapiesinhuman.-
dc.description.sponsorshipTAT was supported by the Fraunhofer Institute for Biomedical Engineering and by the University of Saarland. LG was supported by the Max Planck Institute for Molecular Biomedicine, the Deutscher Akademischer Austauschdienst (grant no. 50753940), the Fraunhofer Institute for Biomedical Engineering and the University of Hasselt. The authors would like to thank Mr. Ben Fischer and Ms. Anna Meier for critical reading of the manuscript-
dc.language.isoen-
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD-
dc.rights2018 Elsevier Ltd. All rights reserved-
dc.subject.otherNeoblast-
dc.subject.otherPotency state transitions-
dc.subject.otherStem cell heterogeneity-
dc.subject.otherCLOUD-
dc.subject.otherBadlands landscape-
dc.subject.otherLive cell tracking-
dc.titleA lineage CLOUD for neoblasts-
dc.typeJournal Contribution-
dc.identifier.epage29-
dc.identifier.issueSI-
dc.identifier.spage22-
dc.identifier.volume87-
local.bibliographicCitation.jcatA1-
dc.description.notesGentile, L (reprint author), Fraunhofer Inst Biomed Engn, Pluripotency & Regenerat Grp, Joseph von Fraunhofer Weg 1, D-66280 Sulzbach, Germany. mckind75@gmail.com-
local.publisher.place24-28 OVAL RD, LONDON NW1 7DX, ENGLAND-
local.type.refereedRefereed-
local.type.specifiedReview-
dc.identifier.doi10.1016/j.semcdb.2018.04.012-
dc.identifier.isi000458768200004-
dc.identifier.eissn1096-3634-
local.uhasselt.internationalyes-
item.accessRightsOpen Access-
item.fullcitationTran, Thao Anh & GENTILE, Luca (2018) A lineage CLOUD for neoblasts. In: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 87 (SI), p. 22-29.-
item.fulltextWith Fulltext-
item.contributorTran, Thao Anh-
item.contributorGENTILE, Luca-
crisitem.journal.issn1084-9521-
crisitem.journal.eissn1096-3634-
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