Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28200
Title: | Prognostic value of total lesion glycolysis and metabolic active tumor volume in non-small cell lung cancer | Authors: | VANHOVE, Karolien MESOTTEN, Liesbet Heylen, Micheline Derwael, Ruben LOUIS, Evelyne ADRIAENSENS, Peter THOMEER, Michiel Boellaard, Ronald |
Issue Date: | 2018 | Source: | Cancer Treatment and Research Communications, 15, p. 7-12 | Abstract: | Introduction: To predict the outcome of patients with non-small cell lung cancer (NSCLC) the currently used prognostic system (TNM) is not accurate enough. The prognostic significance of the SUVmax measured by PET remains controversial. This study aims to evaluate the prognostic value in overall survival and progression free survival of SUVmax, the total lesion glycolysis (TLG) and the mean metabolic active volume (MATV) in NSCLC. Methods: We retrospectively reviewed 105 patients (72 males, 33 females) with a new diagnosis of NSCLC (TNM stage I: 27.6%, II: 10.5%, III: 40.9% and IV: 21.0%) who underwent scanning with a PET/CT. For VOI definition a semi-automatic delineation tool was used. On PET images SUVmax, SUVmean and MATV of the primary tumor and the whole tumor burden were measured. TLG and MATV were measured by using a threshold of 50% of SUVmax. Results: OS and PFS are found to be higher in patients with low-SUVTmax and low-TLGT values. OS and PFS were significantly higher for low-SUVWTBmax, low-MATVWTB and low-TLGWTB values of the whole-tumor burden. Multivariate analysis of the whole-tumor burden revealed that the most important prognostic factors for OS are high MATVWTB and TLGWTB values, increasing stage and male gender. TLGWTB and stage are also independent prognosticators in PFS. Conclusion: Only whole-body TLG is of prognostic value in NSCLC for both OS and PFS. Stratification of patients by TLGWTB might complement outcome prediction but the TNM stage remains the most important determinant of prognosis. Microabstract: In order to predict the outcome of patients with non-small cell lung cancer (NSCLC) the currently used prognostic system (TNM) is not accurate enough. The prognostic significance of the standard uptake value (SUV) measured by PET remains controversial. This study aims to evaluate the prognostic value in overall survival (OS) and progression free survival (PFS) of the standard uptake value (SUV), the total lesion glycolysis (TLG) and the mean metabolic active volume (MATV) in NSCLC. The study reveals that TLG of the whole-tumor burden is an independent prognostic factor for OS and PFS in patients with NSCLC. | Document URI: | http://hdl.handle.net/1942/28200 | ISSN: | 2468-2942 | DOI: | 10.1016/j.ctarc.2017.11.005 | Rights: | 2017 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | vabb 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PETartikel.pdf Restricted Access | Published version | 431.02 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
6
checked on Sep 5, 2020
Page view(s)
104
checked on Sep 7, 2022
Download(s)
82
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.