Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28236
Title: | Controversies and prospects about microglia in maternal immune activation models for neurodevelopmental disorders. | Authors: | SMOLDERS, Silke Notter, Tina SMOLDERS, Sophie RIGO, Jean-Michel BRONE, Bert |
Issue Date: | 2018 | Source: | BRAIN BEHAVIOR AND IMMUNITY, 73, p. 51-65 | Abstract: | Activation of the maternal immune system during pregnancy is a well-established risk factor for neuropsychiatricdisease in the offspring, yet, the underlying mechanisms leading to altered brain function remain largely un-defined. Microglia, the resident immune cells of the brain, are key to adequate development of the centralnervous system (CNS), and are prime candidates to mediate maternal immune activation (MIA)-induced brainabnormalities. As such, the effects of MIA on the immunological phenotype of microglia has been widely in-vestigated. However, contradicting results due to differences in read-out and methodological approaches impedefinal conclusions on MIA-induced microglial alterations. The aim of this review is to critically discuss the evi-dence for an activated microglial phenotype upon MIA. | Keywords: | Maternal immune activation; Microglia; Neurodevelopmental disorders; Poly(I:C); LPS | Document URI: | http://hdl.handle.net/1942/28236 | Link to publication/dataset: | https://ac.els-cdn.com/S0889159118302174/1-s2.0-S0889159118302174-main.pdf?_tid=edc0242e-80cd-4b65-8db5-e1fd04361e0b&acdnat=1544191625_b51fd69040606e9658d4c0cb7257700c | ISSN: | 0889-1591 | e-ISSN: | 1090-2139 | DOI: | 10.1016/j.bbi.2018.06.001 | ISI #: | 000445440900006 | Rights: | 2018 Elsevier Inc. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Manuscript Smolders et al. clean version.pdf | Peer-reviewed author version | 507.23 kB | Adobe PDF | View/Open |
1-s2.0-S0889159118302174-main.pdf Restricted Access | Published version | 417.76 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
15
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
62
checked on Oct 11, 2024
Page view(s)
124
checked on Sep 7, 2022
Download(s)
740
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.