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http://hdl.handle.net/1942/28332
Title: | The physiology of foamy phagocytes in multiple sclerosis | Authors: | GRAJCHEN, Elien HENDRIKS, Jerome BOGIE, Jeroen |
Issue Date: | 2018 | Source: | Acta Neuropathologica Communications, 6 (Art N° 124) | Abstract: | Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions mainly consist of macrophages and microglia containing abundant intracellular myelin remnants. Initial studies showed that these foamy phagocytes primarily promote MS disease progression by internalizing myelin debris, presenting brain-derived autoantigens, and adopting an inflammatory phenotype. However, more recent studies indicate that phagocytes can also adopt a beneficial phenotype upon myelin internalization. In this review, we summarize and discuss the current knowledge on the spatiotemporal physiology of foamy phagocytes in MS lesions, and elaborate on extrinsic and intrinsic factors regulating their behavior. In addition, we discuss and link the physiology of myelin-containing phagocytes to that of foamy macrophages in other disorders such atherosclerosis. | Keywords: | Macrophage; Microglia; Polarization; Neuroinflammation; Remyelination; Multiple sclerosis | Document URI: | http://hdl.handle.net/1942/28332 | ISSN: | 2051-5960 | e-ISSN: | 2051-5960 | DOI: | 10.1186/s40478-018-0628-8 | ISI #: | 000459677800001 | Rights: | © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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s40478-018-0628-8.pdf | Published version | 6.19 MB | Adobe PDF | View/Open |
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