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http://hdl.handle.net/1942/28359
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DC Field | Value | Language |
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dc.contributor.author | Smit, Suzanne | - |
dc.contributor.author | ABRAMS, Steven | - |
dc.contributor.author | Dorny, Pierre | - |
dc.contributor.author | Speybroeck, Nico | - |
dc.contributor.author | Devleesschauwer, Brecht | - |
dc.contributor.author | Hutse, Veronik | - |
dc.contributor.author | Jansens, Hilde | - |
dc.contributor.author | Theeten, Heidi | - |
dc.contributor.author | Beutels, Philippe | - |
dc.contributor.author | HENS, Niel | - |
dc.date.accessioned | 2019-06-05T14:56:40Z | - |
dc.date.available | 2019-06-05T14:56:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | EPIDEMIOLOGY AND INFECTION, 147 (Art N° e154) | - |
dc.identifier.issn | 0950-2688 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28359 | - |
dc.description.abstract | Cytomegalovirus (CMV) infection is endemic worldwide but its seroprevalence varies widely. The goal of this study was to estimate the age-specific seroprevalence of CMV infection in Belgium based on two cross-sectional serological datasets from 2002 and 2006. The seroprevalence was estimated relying on diagnostic test results based on cut-off values pre-specified by the manufacturers of the tests as well as relying on mixture models applied to continuous pathogen-specific immunoglobulin G antibody titre concentrations. The age-specific seroprevalence of hepatitis A virus (HAV), based on three Belgian cross-sectional serological datasets from 1993, 2002 and 2006, was used as a comparator since individuals acquire lifelong immunity upon recovery, implying an increasing seroprevalence with age. The age group weighted overall CMV seroprevalence derived from the mixture model was 32% (95% confidence interval (CI) 31–34%) in 2002 and 31% (95% CI 30–32%) in 2006. We demonstrated that CMV epidemiology differs from the immunizing infection HAV. This was the first large-scale study of CMV and HAV serial datasets in Belgium, estimating seroprevalence specified by age and birth cohort. | - |
dc.description.sponsorship | GSAS was supported by the Research Foundation Flanders - (FWO Aspirant), Brussels, Belgium. NH gratefully acknowledges support from the University of Antwerp scientific chair in Evidence-Based Vaccinology, financed by a gift from Pfizer (2009-2017) and GSK (2016). This research was supported by the Antwerp Study Centre for Infectious Diseases (ASCID) and is part of a project that has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement 682540 - TransMID). | - |
dc.language.iso | en | - |
dc.rights | © The Author(s) 2019. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited | - |
dc.subject.other | Cytomegalovirus; hepatitis A virus; estimating age and birth cohort-specific seroprevalence; seroincidence; mixture modelling | - |
dc.title | The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006: a comparative analysis with hepatitis A virus seroprevalence | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 147 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Smit, GSA (reprint author), Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, Merelbeke, Belgium. ITM, Dept Biomed Sci, Antwerp, Belgium. Catholic Univ Louvain, Inst Hlth & Soc IRSS, Brussels, Belgium. suzanne.smit@ugent.be | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e154 | - |
dc.identifier.doi | 10.1017/s0950268819000487 | - |
dc.identifier.isi | 000475912200085 | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Smit, Suzanne; ABRAMS, Steven; Dorny, Pierre; Speybroeck, Nico; Devleesschauwer, Brecht; Hutse, Veronik; Jansens, Hilde; Theeten, Heidi; Beutels, Philippe & HENS, Niel (2019) The seroprevalence of cytomegalovirus infection in Belgium anno 2002 and 2006: a comparative analysis with hepatitis A virus seroprevalence. In: EPIDEMIOLOGY AND INFECTION, 147 (Art N° e154). | - |
item.accessRights | Open Access | - |
item.contributor | Smit, Suzanne | - |
item.contributor | ABRAMS, Steven | - |
item.contributor | Dorny, Pierre | - |
item.contributor | Speybroeck, Nico | - |
item.contributor | Devleesschauwer, Brecht | - |
item.contributor | Hutse, Veronik | - |
item.contributor | Jansens, Hilde | - |
item.contributor | Theeten, Heidi | - |
item.contributor | Beutels, Philippe | - |
item.contributor | HENS, Niel | - |
crisitem.journal.issn | 0950-2688 | - |
crisitem.journal.eissn | 1469-4409 | - |
Appears in Collections: | Research publications |
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seroprevalence_of_cytomegalovirus_infection_in_belgium_anno_2002_and_2006_a_comparative_analysis_with_hepatitis_a_virus_seroprevalence.pdf | Published version | 601.36 kB | Adobe PDF | View/Open |
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