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Title: | The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation: executive summary | Authors: | Steffel, Jan Verhamme, Peter Potpara, Tatjana S. Albaladejo, Pierre Antz, Matthias DESTEGHE, Lien Haeusler, Karl Georg Oldgren, Jonas Reinecke, Holger Roldan-Schilling, Vanessa Rowell, Nigel Sinnaeve, Peter Collins, Ronan Camm, A. John HEIDBUCHEL, Hein |
Issue Date: | 2018 | Publisher: | OXFORD UNIV PRESS | Source: | EUROPACE, 20(8), p. 1231-1242 | Abstract: | The current manuscript is the Executive Summary of the second update to the original Practical Guide, published in 2013. Non-vitamin K antagonist oral anticoagulants (NOACs) are an alternative for vitamin K antagonists (VKAs) to prevent stroke in patients with atrial fibrillation (AF), and have emerged as the preferred choice, particularly in patients newly started on anticoagulation. Both physicians and patients are becoming more accustomed to the use of these drugs in clinical practice. However, many unresolved questions on how to optimally use these agents in specific clinical situations remain. The European Heart Rhythm Association (EHRA) set out to co-ordinate a unified way of informing physicians on the use of the different NOACs. A writing group identified 20 topics of concrete clinical scenarios for which practical answers were formulated, based on available evidence. The 20 topics are (i) eligibility for NOACs; (ii) practical start-up and follow-up scheme for patients on NOACs; (iii) ensuring adherence to prescribed oral anticoagulant intake; (iv) switching between anticoagulant regimens; (v) pharmacokinetics and drug drug interactions of NOACs; (vi) NOACs in patients with chronic kidney or advanced liver disease; (vii) how to measure the anticoagulant effect of NOACs; (viii) NOAC plasma level measurement rare indications, precautions, and potential pitfalls; (ix) how to deal with dosing errors; (x) what to do if there is a (suspected) overdose without bleeding, or a clotting test is indicating a potential risk of bleeding (xi) management of bleeding under NOAC therapy; (xii) patients undergoing a planned invasive procedure, surgery or ablation; (xiii) patients requiring an urgent surgical intervention; (xiv) patients with AF and coronary artery disease; (xv) avoiding confusion with NOAC dosing across indications; (xvi) cardioversion in a NOAC-treated patient; (xvii) AF patients presenting with acute stroke while on NOACs; (xviii) NOACs in special situations; (xix) anticoagulation in AF patients with a malignancy, and (xx) optimizing dose adjustments of VKA. Additional information and downloads of the text and anticoagulation cards in different languages can be found on an EHRA web site (www.NOACforAF.eu) | Notes: | [Steffel, Jan] Univ Heart Ctr Zurich, Dept Cardiol, Ramistr 100, CH-8091 Zurich, Switzerland. [Verhamme, Peter; Sinnaeve, Peter] Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium. [Potpara, Tatjana S.] Univ Belgrade, Sch Med, Belgrade, Serbia. [Albaladejo, Pierre] Grenoble Alps Univ Hosp, Grenoble, France. [Antz, Matthias] City Hosp Braunschweig, Braunschweig, Germany. [Desteghe, Lien; Heidbuchel, Hein] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Haeusler, Karl Georg] Charite Univ Med Berlin, Ctr Stroke Res Berlin, Berlin, Germany. [Haeusler, Karl Georg] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany. [Oldgren, Jonas] Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden. [Oldgren, Jonas] Uppsala Univ, Dept Med Sci, Uppsala, Sweden. [Reinecke, Holger] Univ Hosp Munster, Dept Cardiovasc Med, Munster, Germany. [Roldan-Schilling, Vanessa] Univ Murcia, Murcia, Spain. [Rowell, Nigel] Tallaght Hosp, Age Related Hlth Care & Stroke Serv, Dublin, Ireland. [Collins, Ronan] St Georges Univ, Cardiol Clin Acad Grp, Mol & Clin Sci Inst, London, England. [Camm, A. John] Imperial Coll, London, England. [Heidbuchel, Hein] Antwerp Univ, Antwerp, Belgium. [Heidbuchel, Hein] Univ Hosp, Antwerp, Belgium. | Keywords: | Non-vitamin K antagonist oral anticoagulants; Vitamin K antagonist; Atrial fibrillation; Stroke;Non-vitamin K antagonist oral anticoagulants; Vitamin K antagonist; Atrial fibrillation; Stroke | Document URI: | http://hdl.handle.net/1942/28441 | ISSN: | 1099-5129 | e-ISSN: | 1532-2092 | DOI: | 10.1093/europace/euy054 | ISI #: | 000440944300001 | Rights: | The Author(s) 2018. For permissions, please email: journals.permissions@oup.com. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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