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Title: | Zoledronic Acid Induces Site-Specific Structural Changes and Decreases Vascular Area in the Alveolar Bone | Authors: | Silveira Soares, Mariana Quirino Van Dessel, Jeroen Jacobs, Reinhilde da Silva Santos, Paulo Sergio Cestari, Tania Mary Garlet, Gustavo Pompermaier Hungaro Duarte, Marco Antonio Nozu Imada, Thais Sumie LAMBRICHTS, Ivo Fischer Rubira-Bullen, Izabel Regina |
Issue Date: | 2018 | Publisher: | W B SAUNDERS CO-ELSEVIER INC | Source: | JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 76(9), p. 1893-1901 | Abstract: | Purpose: The aim was to assess the effect of a relevant regimen of zoledronic acid (ZA) treatment for the study of bisphosphonate-related osteonecrosis of the jaw on alveolar bone microstructure and vasculature. A sub-objective was to use 3-dimensional imaging to describe site-specific changes induced by ZA in the alveolar bone. Materials and Methods: Five Wistar rats received ZA (0.6 mg/kg) and five (controls) received saline solution in the same volume. The compounds were administered intraperitoneally in 5 doses every 28 days. The rats were euthanized 150 days after therapy onset. The mandibles were scanned using high-resolution (14-mu m) micro-computed tomography (micro-CT), decalcified, cut into slices for histologic analysis (5 mu m), and stained with hematoxylin-eosin. Bone quality parameters were calculated using CTAnalyser software (Bruker, Kontich, Belgium) in 2 different volumes of interest (VOIs): the region between the first molar roots (VOI-1) and the periapical region under the first and second molars' apex (VOI-2). Blood vessel density and bone histomorphometric parameters were calculated only for the region between the roots of the first molar using AxioVision Imaging software (version 4.8; Carl Zeiss, Gottingen, Germany). Results: ZA-treated rats showed a significant increase in percentage of bone volume and density (P < .05), with thicker and more connected trabeculae. Furthermore, the ZA group showed a significant decrease in the size of the marrow spaces and nutritive canals and in blood vessel density (P < .05). In the micro-CT evaluation, VOI-2 showed better outcomes in measuring the effect of ZA on alveolar bone. Conclusions: ZA treatment induced bone corticalization and decreased alveolar bone vascularization. VOI-2 should be preferred for micro-CT evaluation of the effect of bisphosphonates on alveolar bone. This analysis allowed the effect of ZA on alveolar bone and its vascularization to be characterized. The results of this analysis may add further knowledge to the understanding of the physiopathology of osteonecrosis of the jaw. (C) 2018 American Association of Oral and Maxillofacial Surgeons | Notes: | [Silveira Soares, Mariana Quirino; da Silva Santos, Paulo Sergio; Fischer Rubira-Bullen, Izabel Regina] Univ Sao Paulo, Bauru Sch Dent, Dept Surg Stomatol Pathol & Radiol, Alameda Dr Otavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, Brazil. [Silveira Soares, Mariana Quirino; Van Dessel, Jeroen; Jacobs, Reinhilde] Katholieke Univ Leuven, Dept Imaging & Pathol, Fac Med, OMFS IMPATH Res Grp, Leuven, Belgium. [Silveira Soares, Mariana Quirino; Van Dessel, Jeroen] Univ Hosp Leuven, Oral & Maxillofacial Surg, Leuven, Belgium. [Van Dessel, Jeroen] Karolinska Inst, Dept Dent Med, Stockholm, Sweden. [Cestari, Tania Mary; Garlet, Gustavo Pompermaier] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Bauru, Brazil. [Hungaro Duarte, Marco Antonio] Univ Sao Paulo, Bauru Sch Dent, Dept Dent Endodont & Dent Mat, Bauru, Brazil. [Nozu Imada, Thais Sumie] Univ Ctr Grande Dourados, Dept Radiol & Pathol, Dourados, Brazil. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. | Keywords: | Activity-based model; validation; sequence alignment methods; classification methods; process models; ALBATROSS | Document URI: | http://hdl.handle.net/1942/28498 | ISSN: | 0278-2391 | e-ISSN: | 1531-5053 | DOI: | 10.1016/j.joms.2018.03.007 | ISI #: | 000442756400020 | Rights: | 2018 Informa UK Limited, trading as Taylor & Francis Group | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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soares2018.pdf | Peer-reviewed author version | 3.84 MB | Adobe PDF | View/Open |
A validation measure for computational scheduler activity based transportation models based on sequence alignment methods.pdf Restricted Access | Published version | 1.83 MB | Adobe PDF | View/Open Request a copy |
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