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Title: | Development of a scoring method to visually score cortical interruptions on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis and healthy controls | Authors: | Scharmga, Andrea Peters, Michiel VAN DEN BERGH, Joop GEUSENS, Piet Loeffen, Daan Van Rietbergen, Bert Schoonbrood, Thea Vosse, Debby Weijers, Rene Van Tubergen, Astrid |
Issue Date: | 2018 | Publisher: | PUBLIC LIBRARY SCIENCE | Source: | PLOS ONE, 13(7) (ART N° e0200331) | Abstract: | Objectives To develop a scoring method to visually score cortical interruptions in finger joints on High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT), determine its intra-and inter-reader reliability and test its feasibility. Methods The scoring method was developed by integrating results from in-depth discussions with experts, consensus meetings, multiple reading experiments and the literature. Cortical interruptions were scored by two independent readers in an imaging dataset with finger joints from patients with rheumatoid arthritis (RA) and healthy controls and assessed for adjacent trabecular distortion. Reliability for the total number of cortical interruptions per joint and per quadrant was calculated using intraclass correlation coefficient (ICC). Feasibility was tested by recording the time to analyze one joint. Results In 98 joints we identified 252 cortical interruptions, 17% had trabecular distortion. Mean diameter of the interruptions was significantly larger in patients with RA compared with healthy controls (0.88 vs 0.47 mm, p = 0.03). Intra-reader reliability was ICC 0.88 (95% CI 0.83;0.92) per joint and ICC 0.69 (95% CI 0.65;0.73) per quadrant. Inter-reader reliability was ICC 0.48 (95% CI 0.20;0.67) per joint and ICC 0.56 (95% CI 0.49;0.62) per quadrant. The time to score one joint was mean 9.2 (SD 4.9) min. Conclusions This scoring method allows detection of small cortical interruptions on HR-pQCT imaging of finger joints, which is promising for use in clinical studies. | Notes: | [Scharmga, Andrea; Peters, Michiel; van den Bergh, Joop P.; Geusens, Piet; Schoonbrood, Thea; Vosse, Debby; van Tubergen, Astrid] Maastricht Univ, Dept Rheumatol, Med Ctr, Maastricht, Netherlands. [Scharmga, Andrea; Peters, Michiel; van den Bergh, Joop P.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Scharmga, Andrea; Peters, Michiel; Geusens, Piet; van Tubergen, Astrid] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Maastricht, Netherlands. [van den Bergh, Joop P.] Viecuri Med Ctr, Dept Internal Med, Venlo, Netherlands. [van den Bergh, Joop P.; Geusens, Piet] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Loeffen, Daan; Weijers, Rene] Maastricht Univ, Dept Radiol, Med Ctr, Maastricht, Netherlands. [van Rietbergen, Bert] Eindhoven Univ Technol, Dept Med Engn, Eindhoven, Netherlands. [van Rietbergen, Bert] Maastricht Univ, Dept Orthopaed Surg, Med Ctr, Maastricht, Netherlands. | Document URI: | http://hdl.handle.net/1942/28517 | ISSN: | 1932-6203 | e-ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0200331 | ISI #: | 000438035500035 | Rights: | 2018 Scharmga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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scharmga 1.pdf | Published version | 9.03 MB | Adobe PDF | View/Open |
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