Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28606
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dc.contributor.authorVander Meeren, Sam-
dc.contributor.authorHeyrman, Bert-
dc.contributor.authorRenmans, Wim-
dc.contributor.authorBakkus, Marleen-
dc.contributor.authorMAES, Brigitte-
dc.contributor.authorDe Raeve, Hendrik-
dc.contributor.authorSchots, Rik-
dc.contributor.authorJochmans, Kristin-
dc.date.accessioned2019-07-04T07:33:37Z-
dc.date.available2019-07-04T07:33:37Z-
dc.date.issued2018-
dc.identifier.citationANNALS OF HEMATOLOGY, 97(7), p. 1219-1227-
dc.identifier.issn0939-5555-
dc.identifier.urihttp://hdl.handle.net/1942/28606-
dc.description.abstractHigh-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1-4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrospectively evaluated 33 L-MBL cases within our hospital population and compared them to 95 subjects with CLL-like MBL (C-MBL). Diagnoses of L-MBL were based on asymptomatic B cell clones with Matutes score < 3, B cells < 5.0 x 10(3)/mu l, and negative computerized tomography scans. We found that median B cell counts were considerably lower compared to C-MBL (0.6 vs 2.3 x 10(3)/mu l) and remained stable over time. Based on immunophenotyping and immunogenetic profiling, most L-MBL clones did not correspond to known lymphoma entities. A strikingly high occurrence of paraproteinemia (48%), hypogammaglobulinemia (45%), and biclonality (21%) was seen; these incidences being significantly higher than in C-MBL (17, 21, and 5%, respectively). Unrelated monoclonal gammopathy of undetermined significance was a frequent feature, as the light chain type of 5/12 paraproteins detected was different from the clonal surface immunoglobulin. After 46-month median follow-up, 2/24 patients (8%) had progressed towards indolent lymphoma requiring no treatment. In contrast, 41% of C-MBL cases evolved to CLL and 17% required treatment. We conclude that clinical L-MBL is characterized by pronounced immune dysregulation and very slow or absent progression, clearly separating it from its CLL-like counterpart.-
dc.language.isoen-
dc.publisherSPRINGER-
dc.subject.otherMonoclonal B cell lymphocytosis; Chronic lymphocytic leukemia; Non-Hodgkin's lymphoma; MGUS; Immunophenotyping-
dc.titleLymphoma-like monoclonal B cell lymphocytosis in a patient population: biology, natural evolution, and differences from CLL-like clones-
dc.typeJournal Contribution-
dc.identifier.epage1227-
dc.identifier.issue7-
dc.identifier.spage1219-
dc.identifier.volume97-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notes[Vander Meeren, Sam; Renmans, Wim; Bakkus, Marleen; Jochmans, Kristin] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Div Hematol, Dept Biol Clin, Brussels, Belgium. [Heyrman, Bert] ZNA Middelheim, Div Hematol, Dept Internal Med, Antwerp, Belgium. [Maes, Brigitte] Jessa Ziekenhuis, Div Hematol, Dept Clin Biol, Hasselt, Belgium. [De Raeve, Hendrik] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Pathol, Brussels, Belgium. [Schots, Rik] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Div Hematol, Dept Internal Med, Brussels, Belgium.-
local.publisher.placeNEW YORK-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.classdsPublValOverrule/author_version_not_expected-
local.classdsPublValOverrule/internal_author_not_expected-
local.classIncludeIn-ExcludeFrom-List/ExcludeFromFRIS-
dc.identifier.doi10.1007/s00277-018-3282-0-
dc.identifier.isi000433502600007-
item.fulltextWith Fulltext-
item.contributorDe Raeve, Hendrik-
item.contributorRenmans, Wim-
item.contributorBakkus, Marleen-
item.contributorMAES, Brigitte-
item.contributorJochmans, Kristin-
item.contributorVander Meeren, Sam-
item.contributorSchots, Rik-
item.contributorHeyrman, Bert-
item.fullcitationVander Meeren, Sam; Heyrman, Bert; Renmans, Wim; Bakkus, Marleen; MAES, Brigitte; De Raeve, Hendrik; Schots, Rik & Jochmans, Kristin (2018) Lymphoma-like monoclonal B cell lymphocytosis in a patient population: biology, natural evolution, and differences from CLL-like clones. In: ANNALS OF HEMATOLOGY, 97(7), p. 1219-1227.-
item.accessRightsRestricted Access-
crisitem.journal.issn0939-5555-
crisitem.journal.eissn1432-0584-
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