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http://hdl.handle.net/1942/28606
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DC Field | Value | Language |
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dc.contributor.author | Vander Meeren, Sam | - |
dc.contributor.author | Heyrman, Bert | - |
dc.contributor.author | Renmans, Wim | - |
dc.contributor.author | Bakkus, Marleen | - |
dc.contributor.author | MAES, Brigitte | - |
dc.contributor.author | De Raeve, Hendrik | - |
dc.contributor.author | Schots, Rik | - |
dc.contributor.author | Jochmans, Kristin | - |
dc.date.accessioned | 2019-07-04T07:33:37Z | - |
dc.date.available | 2019-07-04T07:33:37Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | ANNALS OF HEMATOLOGY, 97(7), p. 1219-1227 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28606 | - |
dc.description.abstract | High-count monoclonal B cell lymphocytosis (MBL) with a chronic lymphocytic leukemia (CLL) phenotype is a well-known entity, featuring 1-4% annual risk of progression towards CLL requiring treatment. Lymphoma-like MBL (L-MBL), on the other hand, remains poorly defined and data regarding outcome are lacking. We retrospectively evaluated 33 L-MBL cases within our hospital population and compared them to 95 subjects with CLL-like MBL (C-MBL). Diagnoses of L-MBL were based on asymptomatic B cell clones with Matutes score < 3, B cells < 5.0 x 10(3)/mu l, and negative computerized tomography scans. We found that median B cell counts were considerably lower compared to C-MBL (0.6 vs 2.3 x 10(3)/mu l) and remained stable over time. Based on immunophenotyping and immunogenetic profiling, most L-MBL clones did not correspond to known lymphoma entities. A strikingly high occurrence of paraproteinemia (48%), hypogammaglobulinemia (45%), and biclonality (21%) was seen; these incidences being significantly higher than in C-MBL (17, 21, and 5%, respectively). Unrelated monoclonal gammopathy of undetermined significance was a frequent feature, as the light chain type of 5/12 paraproteins detected was different from the clonal surface immunoglobulin. After 46-month median follow-up, 2/24 patients (8%) had progressed towards indolent lymphoma requiring no treatment. In contrast, 41% of C-MBL cases evolved to CLL and 17% required treatment. We conclude that clinical L-MBL is characterized by pronounced immune dysregulation and very slow or absent progression, clearly separating it from its CLL-like counterpart. | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject.other | Monoclonal B cell lymphocytosis; Chronic lymphocytic leukemia; Non-Hodgkin's lymphoma; MGUS; Immunophenotyping | - |
dc.title | Lymphoma-like monoclonal B cell lymphocytosis in a patient population: biology, natural evolution, and differences from CLL-like clones | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1227 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1219 | - |
dc.identifier.volume | 97 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Vander Meeren, Sam; Renmans, Wim; Bakkus, Marleen; Jochmans, Kristin] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Div Hematol, Dept Biol Clin, Brussels, Belgium. [Heyrman, Bert] ZNA Middelheim, Div Hematol, Dept Internal Med, Antwerp, Belgium. [Maes, Brigitte] Jessa Ziekenhuis, Div Hematol, Dept Clin Biol, Hasselt, Belgium. [De Raeve, Hendrik] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Dept Pathol, Brussels, Belgium. [Schots, Rik] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Div Hematol, Dept Internal Med, Brussels, Belgium. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
local.class | dsPublValOverrule/internal_author_not_expected | - |
local.class | IncludeIn-ExcludeFrom-List/ExcludeFromFRIS | - |
dc.identifier.doi | 10.1007/s00277-018-3282-0 | - |
dc.identifier.isi | 000433502600007 | - |
item.accessRights | Restricted Access | - |
item.contributor | Vander Meeren, Sam | - |
item.contributor | Heyrman, Bert | - |
item.contributor | Renmans, Wim | - |
item.contributor | Bakkus, Marleen | - |
item.contributor | MAES, Brigitte | - |
item.contributor | De Raeve, Hendrik | - |
item.contributor | Schots, Rik | - |
item.contributor | Jochmans, Kristin | - |
item.fullcitation | Vander Meeren, Sam; Heyrman, Bert; Renmans, Wim; Bakkus, Marleen; MAES, Brigitte; De Raeve, Hendrik; Schots, Rik & Jochmans, Kristin (2018) Lymphoma-like monoclonal B cell lymphocytosis in a patient population: biology, natural evolution, and differences from CLL-like clones. In: ANNALS OF HEMATOLOGY, 97(7), p. 1219-1227. | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 0939-5555 | - |
crisitem.journal.eissn | 1432-0584 | - |
Appears in Collections: | Research publications |
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VanderMeeren2018_Article_Lymphoma-likeMonoclonalBCellLy.pdf Restricted Access | Published version | 666.3 kB | Adobe PDF | View/Open Request a copy |
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