Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28623
Title: | Rates of asthma exacerbations and mortality and associated factors in Uganda: a 2-year prospective cohort study | Authors: | Kirenga, Bruce J. de Jong, Corina MUGENYI, Levicatus Katagira, Winceslaus Muhofa, Abdallah Kamya, Moses R. Boezen, H. Marlke van der Molen, Thys |
Issue Date: | 2018 | Publisher: | BMJ PUBLISHING GROUP | Source: | THORAX, 73(10), p. 983-985 | Abstract: | Data on asthma treatment outcomes in Africa are limited. 449 patients with asthma (age 5-93 years) in Uganda were followed up for 2 years to determine rates of exacerbations and mortality and associated factors. During follow-up the median number of exacerbations per patient was 1 (IQR 0-5) and 17 patients died (3.7%, 27.3 deaths per 1000 person years). Considering only the first year of follow-up, 59.6% of the patients experienced at least one exacerbation, 32.4% experienced three or more exacerbations. A multivariable model showed that the likelihood of experiencing at least one exacerbation in the first year of follow-up was lower with better baseline asthma control (higher asthma control test (ACT) score), with OR 0.87 (95% Cl: 0.82 to 0.93, P=0.000), and was higher with more exacerbations in the year prior to enrolment (OR for log number of exacerbations 1.28, 95% Cl: 1.04 to 1.57, P=0.018). Better asthma control (OR 0.93, 95% Cl: 0.88 to 0.99, P=0.021) and number of baseline exacerbations (OR 1.35,95% Cl: 1.11 to 1.66, P=0.005) were also the only factors that were independently associated with experiencing three or more exacerbations during the first year of follow-up. The only factor found to he associated with all-cause mortality was FEV1, with higher recent FEV, associated with lower all-cause mortality (OR 0.30, 95% Cl: 0.14 to 0.65; P=0.002). Rates of asthma exacerbations and mortality are high in Uganda and are associated with poor asthma control. Health systems should be strengthened to care for asthma patients. | Notes: | [Kirenga, Bruce J.; Mugenyi, Levicatus; Kamya, Moses R.] Makerere Univ, Coll Hlth Sci, Lung Inst, Kampala, Uganda. [Kirenga, Bruce J.; Katagira, Winceslaus; Muhofa, Abdallah] Makerere Univ, Coll Hlth Sci, Dept Med, Kampala, Uganda. [de Jong, Corina; van der Molen, Thys] Univ Groningen, UMCG, Dept Gen Practice & Elderly Care, GRIAC Primary Care, Groningen, Netherlands. [de Jong, Corina; van der Molen, Thys] Univ Groningen, UMCG, GRIAC, Groningen, Netherlands. [Mugenyi, Levicatus] Univ Hasselt, Ctr Stat, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Boezen, H. Marlke] Univ Groningen, Dept Epidemiol, Groningen, Netherlands. | Document URI: | http://hdl.handle.net/1942/28623 | ISSN: | 0040-6376 | e-ISSN: | 1468-3296 | DOI: | 10.1136/thoraxjnl-2017-211157 | ISI #: | 000446090900016 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
983.full.pdf Restricted Access | Published version | 204.1 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
5
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
20
checked on Oct 14, 2024
Page view(s)
102
checked on Sep 7, 2022
Download(s)
98
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.