Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28629
Title: Haemodynamic or metabolic stimulation tests to reveal the renal functional response: requiem or revival?
Authors: DE MOOR, Bart 
Vanwalleghem, Johan F.
SWENNEN, Quirine 
STAS, Koenraad 
Meijers, Bjorn K. I.
Issue Date: 2018
Publisher: OXFORD UNIV PRESS
Source: CLINICAL KIDNEY JOURNAL, 11(5), p. 623-654
Abstract: Renal stimulation tests document the dynamic response of the glomerular filtration rate (GFR) after a single or a combination of stimuli, such as an intravenous infusion of dopamine or amino acids or an oral protein meal. The increment of the GFR above the unstimulated state has formerly been called the renal functional reserve (RFR). Although the concept of a renal reserve capacity has not withstood scientific scrutiny, the literature documenting renal stimulation merits renewed interest. An absent or a blunted response of the GFR after a stimulus indicates lost or diseased nephrons. This information is valuable in preventing, diagnosing and prognosticating acute kidney injury and pregnancy-related renal events as well as chronic kidney disease. However, before renal function testing is universally practiced, some shortcomings must be addressed. First, a common nomenclature should be decided upon. The expression of RFR should be replaced by renal functional response. Second, a simple protocol must be developed and propagated. Third, we suggest designing prospective studies linking a defective stimulatory response to emergence of renal injury biomarkers, to histological or morphological renal abnormalities and to adverse renal outcomes in different renal syndromes.
Notes: [De Moor, Bart; Swennen, Quirine] Univ Hasselt, Fac Med & Life Sci, Diepenbeek, Belgium. [De Moor, Bart; Vanwalleghem, Johan F.; Stas, Koen J.] Jessa Hosp Hasselt, Dept Nephrol, Hasselt, Belgium. [Meijers, Bjorn K. I.] Univ Ziekenhuis Leuven, Dept Nephrol, Leuven, Belgium. [Meijers, Bjorn K. I.] Katholieke Univ Leuven, Dept Immunol & Microbiol, Fac Med, Leuven, Belgium.
Keywords: protein stimulation test; renal functional reserve; renal functional response; renal stimulation test; renal stress test;protein stimulation test; renal functional reserve; renal functional response; renal stimulation test; renal stress test
Document URI: http://hdl.handle.net/1942/28629
ISSN: 2048-8505
e-ISSN: 2048-8513
DOI: 10.1093/ckj/sfy022
ISI #: 000449492700005
Rights: Copyright The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/ licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
Category: A1
Type: Journal Contribution
Validations: ecoom 2019
Appears in Collections:Research publications

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