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Title: | Progress and perspectives in plant sterol and plant stanol research | Authors: | Jones, Peter J. H. Shamloo, Maryam MacKay, Dylan S. Rideout, Todd C. Myrie, Semone B. Plat, Jogchum Roullet, Jean-Baptiste Baer, David J. Calkins, Kara L. Davis, Harry R. Duell, P. Barton Ginsberg, Henry Gylling, Helena Jenkins, David Luetjohann, Dieter Moghadasian, Mohammad Moreau, Robert A. Mymin, David Ostlund, Richard E., Jr. Ras, Rouyanne T. Reparaz, Javier Ochoa Trautwein, Elke A. Turley, Stephen VANMIERLO, Tim Weingaetner, Oliver |
Issue Date: | 2018 | Publisher: | OXFORD UNIV PRESS INC | Source: | NUTRITION REVIEWS, 76(10), p. 725-746 | Abstract: | Current evidence indicates that foods with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. This review summarizes the recent findings and deliberations of 31 experts in the field who participated in a scientific meeting in Winnipeg, Canada, on the health effects of plant sterols and stanols. Participants discussed issues including, but not limited to, the health benefits of plant sterols and stanols beyond cholesterol lowering, the role of plant sterols and stanols as adjuncts to diet and drugs, and the challenges involved in measuring plant sterols and stanols in biological samples. Variations in interindividual responses to plant sterols and stanols, as well as the personalization of lipid-lowering therapies, were addressed. Finally, the clinical aspects and treatment of sitosterolemia were reviewed. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking. | Notes: | [Jones, Peter J. H.; Myrie, Semone B.] Univ Manitoba, Richardson Ctr Funct Foods & Nutraceut, Winnipeg, MB R3T 6C5, Canada. [Rideout, Todd C.] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY USA. [Jones, Peter J. H.; Shamloo, Maryam; Myrie, Semone B.; Moghadasian, Mohammad] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB, Canada. [Shamloo, Maryam; MacKay, Dylan S.] Univ Manitoba, George & Fay Yee Ctr Healthcare Innovat, Winnipeg, MB, Canada. [Plat, Jogchum] Maastricht Univ, Dept Human Biol, Maastricht, Netherlands. [Roullet, Jean-Baptiste] Oregon Hlth & Sci Univ, Dept Pediat, Div Metab, Child Dev & Rehabil Ctr Portland, 3181 Sw Sam Jackson Pk Rd, Portland, OR 97201 USA. [Baer, David J.] ARS, USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD USA. [Calkins, Kara L.] Univ Calif Los Angeles, David Geffen Sch Med, Div Neonatol, Dept Pediat, Los Angeles, CA 90095 USA. [Calkins, Kara L.] UCLA Mattels Childrens Hosp, Los Angeles, CA USA. [Davis, Harry R.] CVPath Inst Inc, Gaithersburg, MD USA. [Duell, P. Barton] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97201 USA. [Ginsberg, Henry] Columbia Univ, Inst Human Nutr, Irving Med Ctr, New York, NY 10032 USA. [Gylling, Helena] Univ Helsinki, Helsinki, Finland. [Gylling, Helena] Univ Helsinki, Cent Hosp, Helsinki, Finland. [Jenkins, David] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada. [Jenkins, David] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON, Canada. [Luetjohann, Dieter] Univ Bonn, Inst Clin Chem & Clin Pharmacol, Bonn, Germany. [Moreau, Robert A.] ARS, Eastern Reg Res Ctr, USDA, Wyndmoor, PA USA. [Mymin, David] Univ Manitoba, Dept Internal Med, Winnipeg, MB, Canada. [Ostlund, Richard E., Jr.] Washington Univ, Div Endocrinol Metab & Lipid Res, St Louis, MO USA. [Ras, Rouyanne T.; Trautwein, Elke A.] Unilever Res Labs, Vlaardingen, Netherlands. [Reparaz, Javier Ochoa] Eastern Washington Univ, Dept Biol, Cheney, WA 99004 USA. [Turley, Stephen] UT Southwestern Med Ctr, Dallas, TX USA. [Vanmierlo, Tim] Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, Hasselt, Belgium. [Weingaetner, Oliver] Friedrich Schiller Univ Jena, Univ Klinikum Jena, Klin Innere Med 1, Jena, Germany. [Weingaetner, Oliver] European Med Sch Oldenburg Groningen, Klinikum Oldenburg, Abt Kardiol, Oldenburg, Germany. | Keywords: | cholesterol;nutrition;plant sterols;plant stanols;sitosterolemia | Document URI: | http://hdl.handle.net/1942/28640 | ISSN: | 0029-6643 | e-ISSN: | 1753-4887 | DOI: | 10.1093/nutrit/nuy032 | ISI #: | 000456017100001 | Rights: | The Author(s) 2018. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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WeingÀrtnerfvSterolStanolProceedingManuscriptVersion MS Nov 1st-3.pdf | Peer-reviewed author version | 802.91 kB | Adobe PDF | View/Open |
OP-NUTR180032 725..746.pdf Restricted Access | Published version | 473.31 kB | Adobe PDF | View/Open Request a copy |
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