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Title: | High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity | Authors: | WILLEBRAND, Ralf HAMAD, Ibrahim VAN ZEEBROECK, Lauren Kiss, Mate Bruderek, Kirsten GEUZENS, Anneleen SWINNEN, Dries FERNANDES CORTE-REAL, Beatriz Marko, Lajos Lebegge, Els Laoui, Damya Kemna, Josephine Kammertoens, Thomas Brandau, Sven Van Ginderachter, Jo A. KLEINEWIETFELD, Markus |
Issue Date: | 2019 | Publisher: | FRONTIERS MEDIA SA | Source: | Frontiers in immunology, 10 (Art N° 1141) | Abstract: | Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on tumor growth in mice. Here we show that high salt significantly inhibited tumor growth in two independent murine tumor transplantation models. Although high salt fed tumor-bearing mice showed alterations in T cell populations, the effect seemed to be largely independent of adaptive immune cells. In contrast, depletion of myeloid-derived suppressor cells (MDSCs) significantly reverted the inhibitory effect on tumor growth. In line with this, high salt conditions almost completely blocked murine MDSC function in vitro. Importantly, similar effects were observed in human MDSCs isolated from cancer patients. Thus, high salt conditions seem to inhibit tumor growth by enabling more pronounced anti-tumor immunity through the functional modulation of MDSCs. Our findings might have critical relevance for cancer immunotherapy. | Notes: | [Willebrand, Ralf; Hamad, Ibrahim; Van Zeebroeck, Lauren; Geuzens, Anneleen; Swinnen, Dries; Corte-Real, Beatriz Fernandes; Kleinewietfeld, Markus] Univ Hasselt, VIB Ctr Inflammat Res, VIB Lab Translat Immunomodulat, Campus Diepenbeek, Hasselt, Belgium. [Kiss, Mate; Lebegge, Els; Laoui, Damya; Van Ginderachter, Jo A.] Vrije Univ Brussel, Cellular & Mol Immunol Lab, Brussels, Belgium. [Kiss, Mate; Lebegge, Els; Laoui, Damya; Van Ginderachter, Jo A.] VIB Ctr Inflammat Res, Myeloid Cell Immunol Lab, Brussels, Belgium. [Bruderek, Kirsten; Brandau, Sven] Univ Hosp Essen, West German Canc Ctr, Dept Otorhinolaryngol, Res Div, Essen, Germany. [Marko, Lajos] Joint Cooperat Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany. [Marko, Lajos] Charite Univ Med Berlin, Berlin, Germany. [Kemna, Josephine; Kammertoens, Thomas] Charite Univ Med Berlin, Inst Immunol, Berlin, Germany. [Kemna, Josephine; Kammertoens, Thomas] Max Delbruck Ctr Mol Med, Berlin, Germany. | Keywords: | cancer; dietary factor; MDSC; cancer immunotherapy; sodium chloride (dietary);cancer; dietary factor; MDSC; cancer immunotherapy; sodium chloride (dietary) | Document URI: | http://hdl.handle.net/1942/28665 | ISSN: | 1664-3224 | e-ISSN: | 1664-3224 | DOI: | 10.3389/fimmu.2019.01141 | ISI #: | 000470195500001 | Rights: | Copyright © 2019 Willebrand, Hamad, Van Zeebroeck, Kiss, Bruderek, Geuzens, Swinnen, Côrte-Real, Markó, Lebegge, Laoui, Kemna, Kammertoens, Brandau, Van Ginderachter and Kleinewietfeld. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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