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http://hdl.handle.net/1942/28670
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DC Field | Value | Language |
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dc.contributor.author | Simon-Martinez, Cristina | - |
dc.contributor.author | Jaspers, Ellen | - |
dc.contributor.author | Alaerts, Kaat | - |
dc.contributor.author | Ortibus, Els | - |
dc.contributor.author | Balsters, Joshua | - |
dc.contributor.author | Mailleux, Lisa | - |
dc.contributor.author | Blommaert, Jeroen | - |
dc.contributor.author | Sleurs, Charlotte | - |
dc.contributor.author | KLINGELS, Katrijn | - |
dc.contributor.author | Amant, Frederic | - |
dc.contributor.author | Uyttebroeck, Anne | - |
dc.contributor.author | Wenderoth, Nicole | - |
dc.contributor.author | Feys, Hilde | - |
dc.date.accessioned | 2019-07-09T09:14:23Z | - |
dc.date.available | 2019-07-09T09:14:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Scientific Reports, 9 (Art N° 8230) | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28670 | - |
dc.description.abstract | In children with unilateral cerebral palsy (uCP), the corticospinal tract (CST)-wiring patterns may differ (contralateral, ipsilateral or bilateral), partially determining motor deficits. However, the impact of such CST-wiring on functional connectivity remains unknown. Here, we explored resting-state sensorimotor functional connectivity in 26 uCP with periventricular white matter lesions (mean age (standard deviation): 12.87 m (+/- 4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) compared to 60 healthy controls (mean age (standard deviation): 14.54 (+/- 4.8)), and between CST-wiring patterns. Functional connectivity from each M1 to three bilateral sensorimotor regions of interest (primary sensory cortex, dorsal and ventral premotor cortex) and the supplementary motor area was compared between groups (controls vs. uCP; and controls vs. each CST-wiring group). Seed-to-voxel analyses from bilateral M1 were compared between groups. Additionally, relations with upper limb motor deficits were explored. Aberrant sensorimotor functional connectivity seemed to be CST-dependent rather than specific from all the uCP population: in the dominant hemisphere, the contra lateral CST group showed increased connectivity between M1 and premotor cortices, whereas the bilateral CST group showed higher connectivity between M1 and somatosensory association areas. These results suggest that functional connectivity of the sensorimotor network is CST-wiring-dependent, although the impact on upper limb function remains unclear. | - |
dc.description.sponsorship | This work is funded by the Fund Scientific Research Flanders (FWO-project, grant G087213N) and by the Special Research Fund, KU Leuven (OT/14/127, project grant 3M140230). J.B. and F.A. have received funding from the Research Foundation Flanders (FWO), who received funding from the European Union's Horizon 2020 research and innovation programme (European Research council, grant no 647047) to collect data of the typically developing individuals. We would like to express our deepest gratitude to the children and families who participated in this study. We also specially thank Jasmine Hoskens for her help during the clinical assessments. | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.rights | The Author(s) 2019 | - |
dc.title | Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 9 | - |
local.format.pages | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Simon-Martinez, Cristina; Alaerts, Kaat; Mailleux, Lisa; Klingels, Katrijn; Feys, Hilde] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. [Jaspers, Ellen; Balsters, Joshua; Wenderoth, Nicole] ETH, Dept Hlth Sci & Technol, Neural Control Movement Lab, Zurich, Switzerland. [Ortibus, Els] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium. [Balsters, Joshua] Royal Holloway Univ London, Dept Psychol, Egham, Surrey, England. [Blommaert, Jeroen; Sleurs, Charlotte; Amant, Frederic; Uyttebroeck, Anne] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium. [Klingels, Katrijn] Hasselt Univ, Fac Rehabil Sci, Rehabil Res Ctr, Diepenbeek, Belgium. [Amant, Frederic] Ctr Gynaecol Oncol, Amsterdam, Netherlands. [Amant, Frederic] Univ Amsterdam, Ctr Gynaecol Oncol, Med Ctr, Amsterdam, Netherlands. | - |
local.publisher.place | LONDON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 8230 | - |
local.type.programme | H2020 | - |
local.relation.h2020 | 647047 | - |
dc.identifier.doi | 10.1038/s41598-019-44728-9 | - |
dc.identifier.isi | 000469913200010 | - |
item.validation | ecoom 2020 | - |
item.accessRights | Open Access | - |
item.fullcitation | Simon-Martinez, Cristina; Jaspers, Ellen; Alaerts, Kaat; Ortibus, Els; Balsters, Joshua; Mailleux, Lisa; Blommaert, Jeroen; Sleurs, Charlotte; KLINGELS, Katrijn; Amant, Frederic; Uyttebroeck, Anne; Wenderoth, Nicole & Feys, Hilde (2019) Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy. In: Scientific Reports, 9 (Art N° 8230). | - |
item.fulltext | With Fulltext | - |
item.contributor | Simon-Martinez, Cristina | - |
item.contributor | Jaspers, Ellen | - |
item.contributor | Alaerts, Kaat | - |
item.contributor | Ortibus, Els | - |
item.contributor | Balsters, Joshua | - |
item.contributor | Mailleux, Lisa | - |
item.contributor | Blommaert, Jeroen | - |
item.contributor | Sleurs, Charlotte | - |
item.contributor | KLINGELS, Katrijn | - |
item.contributor | Amant, Frederic | - |
item.contributor | Uyttebroeck, Anne | - |
item.contributor | Wenderoth, Nicole | - |
item.contributor | Feys, Hilde | - |
crisitem.journal.issn | 2045-2322 | - |
crisitem.journal.eissn | 2045-2322 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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simon 1.pdf | Published version | 3.25 MB | Adobe PDF | View/Open |
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