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Title: | Causal involvement of DLPFC during bimanual coordination in older adults - an rTMS study | Authors: | VERSTRAELEN, Stefanie CUYPERS, Koen Duque, Julie DEPESTELE, Siel VAN DUN, Kim Fujiyama, Hakuei Levin, Oron Swinnen, Stephan P. MEESEN, Raf |
Issue Date: | 2019 | Source: | Frontiers in Neuroscience | Abstract: | The role of the dorsolateral prefrontal cortex (DLPFC) in the regulation of bimanual coordination appears to become crucial with aging. Age-related changes in the involvement of the DLPFC in bimanual coordination were studied by using disruptive repetitive TMS (rTMS), inducing a transient lesion in this brain structure. Neurophysiological as well as behavioral effects of suppressing DLPFC during the preparation and execution of a bimanual task were studied in 41 healthy adults (young and old). Specifically, we combined short-train rTMS with single pulse TMS to examine the effect of DLPFC suppression on the interhemispheric projection to the contralateral primary motor cortex (M1) during motor preparation. Findings revealed that compromised interhemispheric DLPFC-M1 disinhibition during motor preparation in older adults resulted in less accurate bimanual performance. The altered DLPFC-M1 interaction in older adults appeared to result from a decline in local inhibitory mechanisms in the DLPFC. In addition, the induction of DLPFC suppression affected task accuracy, but not movement stability in both age groups. Taken together, these results suggest that DLPFC acts as a key regulator in the control of bimanual movement coordination. | Keywords: | Aging; bimanual coordination; dorsolateral prefrontal cortex (DLPFC); Interhemispheric interaction; repetitive transcranial magnetic stimulation (rTMS) | Document URI: | http://hdl.handle.net/1942/28674 | e-ISSN: | 1662-453X | DOI: | 10.3389/conf.fnins.2019.96.00047 | Rights: | The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. | Category: | M | Type: | Journal Contribution |
Appears in Collections: | Research publications |
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