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http://hdl.handle.net/1942/28682
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DC Field | Value | Language |
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dc.contributor.author | Madsen, Jens Otto Broby | - |
dc.contributor.author | Casteels, Kristina | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Kristensen, Kurt | - |
dc.contributor.author | Vanbrabant, Koen | - |
dc.contributor.author | Ramon-Krauel, Marta | - |
dc.contributor.author | Johannesen, Jesper | - |
dc.contributor.author | Bontinck, Magda | - |
dc.contributor.author | Devisscher, Carine | - |
dc.contributor.author | Goicoechea, Irune | - |
dc.contributor.author | Hertz, Anne Marie | - |
dc.contributor.author | Jorgensen, Lene Kolle | - |
dc.contributor.author | Vandoorne, Eva | - |
dc.contributor.author | Yoldi, Carmen | - |
dc.contributor.author | Casteels, Kristian | - |
dc.contributor.author | Corripio, Raquel | - |
dc.contributor.author | Gonzalez-Vergaz, Amparo | - |
dc.contributor.author | Hernandez, Roque Cardona | - |
dc.contributor.author | Sanchez, Jacobo Perez | - |
dc.contributor.author | Van Aken, Sara | - |
dc.contributor.author | Vanbesien, Jesse | - |
dc.date.accessioned | 2019-07-09T10:51:03Z | - |
dc.date.available | 2019-07-09T10:51:03Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Diabetes Technology & Therapeutics, 21(6), p. 322-328 | - |
dc.identifier.issn | 1520-9156 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28682 | - |
dc.description.abstract | Background: This multicenter crossover study investigated the potential beneficial effect of an automated bolus calculator (ABC) in children and adolescents with type 1 diabetes (T1D) treated with multiple daily injections (MDI). Methods: Participants were randomized to either begin or end with a 5 months intervention versus their regular treatment regimen (control), separated by a 2 months washout period. During the intervention participants were carefully instructed to use the ABC (Accu-Check Aviva Expert) versus manual insulin calculations during the control period. Participants between 8 and 18 years of age with T1D were recruited from clinics in Denmark, Belgium, and Spain. Inclusion criteria included T1D for >1 year, a minimum of 3 months MDI treatment before inclusion, and HbA1c of 7.5%-11% (57-97 mmol/mol). Improvement in HbA1c was the main outcome, and improved quality of life (QoL) and glucose variability (time spent in target glucose) were secondary outcomes. Results: A total of 65 patients with a mean age of 13.25 years and a mean HbA1c of 8.25% (66.7 mmol/mol) were included. Midway evaluation after 2 months of intervention showed no significant difference from the standard care (0.297, 95% confidence interval [CI]: -0.645 to 0.054; P = 0.10). The difference remained insignificant after the 5 months of intervention (-0.143 [95% CI: -0.558 to 0.272; P = 0.51]). Using the ABC did not change the time spent in target glucose range, nor did it change the QoL. Conclusions: Our study did not demonstrate beneficial additive effects of an ABC in children and adolescents with T1D treated with MDI neither in HbA1c, nor in any other endpoint investigated. | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.rights | Mary Ann Liebert, Inc | - |
dc.subject.other | Automated bolus calculator; type 1 diabetes; Pediatric; Multiple daily injections | - |
dc.subject.other | Automated bolus calculator; type 1 diabetes; pediatric; multiple daily injections | - |
dc.title | No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections: The Expert Kids Study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 328 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 322 | - |
dc.identifier.volume | 21 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Madsen, Jens Otto Broby; Johannesen, Jesper] Herlev Univ Hosp, Dept Pediat, Herlev, Denmark. [Casteels, Kristina] Univ Hosp Leuven, Dept Pediat, Leuven, Belgium. [Casteels, Kristina] Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium. [Fieuws, Steffen; Vanbrabant, Koen] KU Leuven Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. [Fieuws, Steffen; Vanbrabant, Koen] Univ Hasselt, Leuven, Belgium. [Kristensen, Kurt] Skejby Univ Hosp, Dept Pediat, Aarhus, Denmark. [Ramon-Krauel, Marta] Hosp St Joan de Deu, Inst Recerca St Joan de Deu, Dept Endocrinol, Barcelona, Spain. [Johannesen, Jesper] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark. | - |
local.publisher.place | NEW ROCHELLE | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1089/dia.2019.0064 | - |
dc.identifier.isi | 000470003300004 | - |
item.fullcitation | Madsen, Jens Otto Broby; Casteels, Kristina; FIEUWS, Steffen; Kristensen, Kurt; Vanbrabant, Koen; Ramon-Krauel, Marta; Johannesen, Jesper; Bontinck, Magda; Devisscher, Carine; Goicoechea, Irune; Hertz, Anne Marie; Jorgensen, Lene Kolle; Vandoorne, Eva; Yoldi, Carmen; Casteels, Kristian; Corripio, Raquel; Gonzalez-Vergaz, Amparo; Hernandez, Roque Cardona; Sanchez, Jacobo Perez; Van Aken, Sara & Vanbesien, Jesse (2019) No Effect of an Automated Bolus Calculator in Pediatric Patients with Type 1 Diabetes on Multiple Daily Injections: The Expert Kids Study. In: Diabetes Technology & Therapeutics, 21(6), p. 322-328. | - |
item.contributor | Madsen, Jens Otto Broby | - |
item.contributor | Casteels, Kristina | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Kristensen, Kurt | - |
item.contributor | Vanbrabant, Koen | - |
item.contributor | Ramon-Krauel, Marta | - |
item.contributor | Johannesen, Jesper | - |
item.contributor | Bontinck, Magda | - |
item.contributor | Devisscher, Carine | - |
item.contributor | Goicoechea, Irune | - |
item.contributor | Hertz, Anne Marie | - |
item.contributor | Jorgensen, Lene Kolle | - |
item.contributor | Vandoorne, Eva | - |
item.contributor | Yoldi, Carmen | - |
item.contributor | Casteels, Kristian | - |
item.contributor | Corripio, Raquel | - |
item.contributor | Gonzalez-Vergaz, Amparo | - |
item.contributor | Hernandez, Roque Cardona | - |
item.contributor | Sanchez, Jacobo Perez | - |
item.contributor | Van Aken, Sara | - |
item.contributor | Vanbesien, Jesse | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1520-9156 | - |
crisitem.journal.eissn | 1557-8593 | - |
Appears in Collections: | Research publications |
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10.1089@dia.2019.0064.pdf Restricted Access | Published version | 313.29 kB | Adobe PDF | View/Open Request a copy |
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