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http://hdl.handle.net/1942/28698
Title: | Right ventricular involvement in cardiac sarcoidosis demonstrated with cardiac magnetic resonance | Authors: | Smedema, Jan-Peter van Geuns, Robert-Jan Ainslie, Gillian Ector, Joris HEIDBUCHEL, Hein Crijns, Harry J. G. M. |
Issue Date: | 2017 | Publisher: | WILEY PERIODICALS, INC | Source: | ESC HEART FAILURE, 4(4), p. 535-544 | Abstract: | Aims Cardiac involvement in sarcoidosis is reported in up to 30% of patients. Left ventricular involvement demonstrated by contrast-enhanced cardiac magnetic resonance has been well validated. We sought to determine the prevalence and distribution of right ventricular late gadolinium enhancement in patients diagnosed with pulmonary sarcoidosis. Methods and results We prospectively evaluated 87 patients diagnosed with pulmonary sarcoidosis with contrast-enhanced cardiac magnetic resonance for right ventricular involvement. Pulmonary artery pressures were non-invasively evaluated with Doppler echocardiography. Patient characteristics were compared between the groups with and without right ventricular involvement, and right ventricular enhancement was correlated with pulmonary hypertension, ventricular mass, volume, and systolic function. Left ventricular late gadolinium enhancement was demonstrated in 30 patients (34%). Fourteen patients (16%) had right ventricular late gadolinium enhancement, with sole right ventricular enhancement in only two patients. The pattern of right ventricular enhancement consisted of right ventricular outflow tract enhancement in 1 patient, free wall enhancement in 8 patients, ventricular insertion point enhancement in 10 patients, and enhancement of the right side of the interventricular septum in 11 patients. Pulmonary arterial hypertension correlated with the presence of right ventricular enhancement (P<0.001). Right ventricular enhancement correlated with systolic ventricular dysfunction (P<0.001), hypertrophy (P=0.001), and dilation (P<0.001). Conclusions Right ventricular enhancement was present in 16% of patients diagnosed with pulmonary sarcoidosis and in 48% of patients with left ventricular enhancement. The presence of right ventricular enhancement correlated with pulmonary arterial hypertension, right ventricular systolic dysfunction, hypertrophy, and dilation. | Notes: | [Smedema, Jan-Peter; Crijns, Harry J. G. M.] Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands. [van Geuns, Robert-Jan] Erasmus MC, Dept Cardiol, Rotterdam, Netherlands. [Ainslie, Gillian] Groote Schuur Hosp, Dept Med, Resp Clin, Cape Town, South Africa. [Ector, Joris] Univ Hosp Gasthuisberg, Dept Cardiol, Leuven, Belgium. [Heidbuchel, Hein] Univ Hasselt, Heart Ctr, Virga Jessa Hosp, Hasselt, Belgium. | Keywords: | Cardiomyopathy; Magnetic resonance imaging; Pulmonary hypertension; Right ventricle; Sarcoidosis;Cardiomyopathy; Magnetic resonance imaging; Pulmonary hypertension Right ventricle; Sarcoidosis | Document URI: | http://hdl.handle.net/1942/28698 | ISSN: | 2055-5822 | e-ISSN: | 2055-5822 | DOI: | 10.1002/ehf2.12166 | ISI #: | 000415872600017 | Rights: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in anymedium, provided the original work is properly cited and is not used for commercial purposes. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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Smedema_et_al-2017-ESC_Heart_Failure.pdf | Published version | 384.3 kB | Adobe PDF | View/Open |
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